Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Bromodichloromethane CAS 75-27-4 Assessor A: J Brown - DTS Raeburn Assessor B: D Dyson, URS Final review: Panel/SF
Date 21/05/2009 Date 25/03/2009 Date 09/09/2009
US Agency for Toxic Substances
and Disease Registry (ATSDR)
Toxicological Profiles and
Minimal Risk Levels
drinking water 30 ug/day Surveys of BDCM levels in chlorinated public drinking
water systems across the United States have revealed
that BDCM is present in most systems at concentrations
Furlong and D'itri 1986; Symons et al. 1975). The
estimated exposure of the general human population to
BDCM from drinking water, assuming a median BDCM
concentration of 0.014 mg/L and a water intake for an
adult of 2.18 L/day, would be 0.03 mg/day (EPA 1980a).
Low levels of exposure might also occur by inhalation of
BDCM volatilized from chlorinated water (e.g., while
showering, cooking, or swimming), or by dermal contact
with such water. Based on a chemical structure analogy
to chloroform, an estimated dermal exposure to BDCM
in a child swimming two hours/day in a saline pool
would typically be 0.003 mg/day, with a maximum of
0.04 mg/day (Beech 1980). Higher exposure levels
might occur through ingestion of water contaminated
with BDCM near a waste site, but available data suggest
that this is not a common occurrence.
US Agency for Toxic Substances
and Disease Registry (ATSDR)
Toxicological Profiles and
Minimal Risk Levels
Dec-89 drinking water 40 ug/day Max mean in water of 20ug/l. Adjusted for 2l
consumption
ATSDR, Toxological Profile for
Bromodichlormethane, 1989
www.atsdr.cdc.gov/
USEPA Health Advisories drinking water 16 ug/day Mean of finished concs of 8.2μg/l (surface water) and
7.9μg/l (groundwater) for large-scale US supplies
>100,000 persons (Disinfectants and Disinfection By
products (D/DBPs) ICR Data, U.S. EPA (2001a)).
Converted assuming 2L/day consumed.
see page IV - 1
http://www.epa.gov/waterscience/c
riteria/drinking/brthm-
200605(508).pdf
USEPA Health Advisories Nov-05 drinking water 40 ug/day converted from published mean of 20ug/l for surface
water, assuming 2L/day conscumed
Toxicological Data Network
(TOXNET)
Other
EPA Office of Water, Drinking Water Criteria
Document for Brominated Trihalomethanes,
2005
MDI Recommended MDIinhal Units
15 ug day-1
www.epa.gov/waterscience/criteria
/drinking/
http://toxnet.nlm.nih.gov/
Justification: Most conservative value from most recent study (USEPA, 2005). Published mean. Note: MDI not required as assumed to be non
threhold compound
Organisation Date Media Value Units Description Reference Web link
US Agency for Toxic Substances
and Disease Registry (ATSDR)
Toxicological Profiles and
Minimal Risk Levels
Dec-89 air 1.1ppt (mean value) ATSDR, Toxological Profile for
Bromodichlormethane, 1989
www.atsdr.cdc.gov/
USEPA Health Advisories Nov-05 outdoor air 13.4 ug/day converted from published mean of 0.67ug/m3 EPA Office of Water, Drinking Water Criteria
Document for Brominated Trihalomethanes,
2005
USEPA Health Advisories Nov-05 indoor air 15 ug/day converted from published mean of 0.75ug/m3 EPA Office of Water, Drinking Water Criteria
Document for Brominated Trihalomethanes,
2005
Toxicological Data Network
(TOXNET)
air 74.2 ug/day converted from max value of 3.71 ug/m3 assuming
adult breathes 20 m3/d
1990 drinking water 48 ug/day converted from 24ug/l assuming 2L/day consumed http://toxnet.nlm.nih.gov/cgibin/sis/search/f./temp/~92koTn:2
http://toxnet.nlm.nih.gov/cgibin/sis/search/f./temp/~92koTn:2
www.epa.gov/waterscience/criteria
/drinking/
www.epa.gov/waterscience/criteria
/drinking/
http://toxnet.nlm.nih.gov/
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