Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Bromodichloromethane CAS Number: 75-27-4 Assessor A: J Brown - DTS Raeburn Assessor B: S Cole, URS Final review: Panel/SF
Date 21/05/2009 Date 10/08/2009 Date 08/09/2009
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ Mar-93 18/05/2009 B2; probable human
carcinogen
Based on inadequate human data and Oral slope factor
sufficient evidence of carcinogenicity
in two animal species (mice and rats)
as shown by increased incidence of
kidney tumours and tumours of the
large intestine in male and female
rats, kidney tumours in male mice, and
liver tumours in female mice
0.062 (equivalent (mg/kg/day) -1
to 0.16 ug/kg/d for
lifetime cancer risk
of 10-5)
Adequate numbers of animals were used for a lifetime Linearized multistage method used to derive cancer slope factors from 4.9e-3
bioassay with two animal species.
to 6.2e-2 per mg/kg/d. Most conservative (6.2e-2) adopted by IRIS as the oral
Bromodichloromethane was administered at two dose slope factor.
levels. Tumours of multiple tissue types were observed
in a dose-related manner. Slope factors derived from
tumour incidences of kidney and large intestine are
similar and within one order of magnitude in differences.
ID inhal Recommended IDinhal Units
n/a
Justification
No information available.
Organisation Web Link Last Updated Date Web Checked Non threshold
effects
Basis Health criteria type Value Units Confidence rating Basis
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