Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Bromodichloromethane CAS Number: 75-27-4 Assessor A: J Brown - DTS Raeburn Assessor B: S Cole, URS Final review: Panel/SF
Date 21/05/2009 Date 10/08/2009 Date 08/09/2009
Oral Dermal Inhalation Combine Oral and
Inhalation TDIs
Justification
Apply TDIoral to exposure routes
No No No
Apply IDoral to exposure routes
Apply TDIinh to exposure routes
Yes Yes Yes
No No No
NR
Group 2B - probably carcinogenic to humans. No inhalation
data available. IDoral applied to oral, dermal and
inhalation exposure.
Apply IDinh to exposure routes
No No No
TDI oral Recommended TDIoral Units
3 ug.kg(BW) -1 .day -1
Justification
More conservative and more recently derived RfD from USEPA Health Advisors preferred to older ATSDR and IRIS health criteria.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
Drinking Water Inspectorate (DWI) http://www.dwi.gov.uk/ 30/03/2009 DWS 100 μg/l 2.86
Confidence rating Basis Value Units UF UF description
US Agency for Toxic Substances and
Disease Registry (ATSDR) Toxicological
Profiles and Minimal Risk levels
http://www.atsdr.cdc.gov/ Dec-89 15/05/2009 Chronic MRL 0.018 mg/kg/day 18 LOAEL 25 mg/kg/day 1000 10 for: extrapolation from animals to
humans, special variation and use of a
LOAEL. LOAEL also adjusted for
intermittent exposure.
USEPA Health Advisors
http://www.epa.gov/waterscience/criteria/
drinking
15-11-2005 30/03/2009 Longer-term health
advisory (HA)
2 mg/L 60 (assuming 70 kg
adult that drinks 2
L water per day)
BMDL10 18 mg/kg-bw/day 300 Uncertainty factor based on NAS/OW
guidelines. This value includes a factor
of 10 to protect sensitive human
populations and a factor of 10 for
extrapolation from animals to
humans, and a factor of 3 to account
for uncertainty regarding possible
reproductive effects of
bromodichloromethane in humans.
HA quoted in L/day in document.
USEPA Health Advisors
http://www.epa.gov/waterscience/criteria/
drinking
15-11-2005 30/03/2009 RfD 0.003 mg/kg-day 3 BMDL10 0.8 mg/kg-bw/day 300 Uncertainty factor based on NAS/OW
guidelines. This value includes a factor
of 10 to protect sensitive human
populations and a factor of 10 for
extrapolation from animals to
humans, and a factor of 3 to account
for uncertainty regarding possible
reproductive effects of
bromodichloromethane in humans
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ Mar-91 18/05/2009 RfD 0.02 mg/kg/day 20 medium LOAEL 17.9 mg/kg/day 1000 10 for: extrapolation from animals to
humans, special variation and use of a
LOAEL. LOAEL also adjusted for
treatment schedule.
Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ May-09 18/05/2009 NOAEL 20.6 mg/kg/day
TDI inhal Recommended TDIinhal Units
n/a
Justification
No information available.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
Confidence rating Basis Value Units UF UF description
Page 1 of 6 EIC_proforma_bromodichloromethane 09/09/2009