Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Bromobenzene
Joint Expert Committee on Food Additives
(JECFA)
Study of nephrotoxicity of 2-BP, a metabolite of
bromobenzene.
kidney
http://whqlibdoc.who.int/publications/2005/9241530669_eng.pdf
USEPA Integrated Risk Information System
(IRIS)
mice and rats
two 90 day gavage studies (1 in rats and 1 in
mice)
2,4,6-TRIBROMOPHENOL AND OTHER SIMPLE BROMINATED PHENOLS. First
draft prepared by Mr P.D. Howe, Dr S. Dobson, and Mr H.M. Malcolm,
Centre for Ecology & Hydrology, Monks Wood, United Kingdom.
Liver toxicity in female mice, as defined by Toxicological review of bromobenzene (EPA/635/R-07/002) June 2007. http://cfpub.epa.gov/ncea/cfm/iris/recordisplay.cfmdeid=173309
an increase in liver weight and liver NOTE, DRAFT REPORT NOT FOR CITATION OR QUOTATION.
lesions was selected as the critical effect
for deriving the chronic RfD
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
rats & mice
rats and mice receiving bromobenzene by
gavage 5 days/week for 13 weeks
liver lesions in male and female Provisional Peer Reviewed Toxicity Values for Bromobenzene (CASRN 108-
86-1). Derivation of a Chronic Oral RfD
NA
PRG region 9
unknown unknown USEPA Region 9. Preliminary Remediation Goals, Screening Levels for
Contaminants. Accessed 18th May 2009.
http://www.epa.gov/region09/superfund/prg/files/04prgtable.pdf
The Risk Assessment Information System
rat and mouse unknown microscopic liver lesions Risk Assessment Information System (RAIS). Accessed 18th May 2009. http://rais.ornl.gov/cgi-bin/tox/TOX_selectselect=chem
Texas Commission on Environmental
Quality. Texas Risk Reduction Program
Protective Concentration Levels
unknown unknown Texas Commission on Environmental Quality. Texas Risk Reduction
Program Protective Concentration Levels. Accessed 20th May 2009.
http://www.tceq.state.tx.us/remediation/trrp/trrppcls.html
TDI inhal
Organisation
Study type Description Response Reference Web link
Health and Safety Executive (HSE)
USEPA Integrated Risk Information System
(IRIS)
rats and mice
retention index of VOCs MDHS 96 volatile organic compounds in air, March 2000 http://www.hse.gov.uk/pubns/mdhs/pdfs/mdhs96.pdf
two 13-week studies, one in rats and one in increased occurrence of cytomegaly and Toxicological review of bromobenzene (EPA/635/R-07/002) June 2007. http://cfpub.epa.gov/ncea/cfm/iris/recordisplay.cfmdeid=173309
mice.
increased absolute and relative liver NOTE, DRAFT REPORT NOT FOR CITATION OR QUOTATION.
weight in female mice was selected as
potential critical effects for deriving the
subchronic RfC.
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
mice
mice exposed tp 0, 30, 100 or 300 ppm mild centrilobular hepatocellular
bromobenzene 6hours/day, 5 days/week for 13 hypertrophy in male mice
weeks.
Provisional Peer Reviewed Toxicity Values for Bromobenzene (CASRN 108-
86-1). Derivation of a Chronic Inhalation RfC
NA
PRG region 9
unknown unknown USEPA Region 9. Preliminary Remediation Goals, Screening Levels for
Contaminants. Accessed 18th May 2009.
http://www.epa.gov/region09/superfund/prg/files/04prgtable.pdf
The Risk Assessment Information System
mouse unknown microscopic liver lesions Risk Assessment Information System (RAIS). Accessed 18th May 2009. http://rais.ornl.gov/cgi-bin/tox/TOX_selectselect=chem
Texas Commission on Environmental
Quality. Texas Risk Reduction Program
Protective Concentration Levels
unknown unknown Texas Commission on Environmental Quality. Texas Risk Reduction
Program Protective Concentration Levels. Accessed 20th May 2009.
http://www.tceq.state.tx.us/remediation/trrp/trrppcls.html
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EIC proforma bromobenzene.xls28/08/2009