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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Bromobenzene TDI oral Organisation Study type Description Target organ/Critical Effect Reference Web link Food Standards Agency (FSA) rats Dosing of bromobenzene to give rise to overt liver toxicity. liver toxicity Hiejne WHM et al Toxicogenomics of bromobenzene hepatotoxicity: combined transcriptomics and proteomics approach. Biochemical Pharmacology, 65, 857-875, 2003. http://cot.food.gov.uk/pdfs/TOX-2004-02annexes.pdf Committee on the Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC) rats liver toxicity (no definite conclusions drawn in the study). NOTE, DRAFT PAPER ONLY FOR DISCUSSION. COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS AND THE ENVIRONMENT (COT) http://www.iacoc.org.uk/papers/documents/cc046.pdf Committee on the Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM) rats liver toxicity (no definite conclusions drawn in the study). NOTE, DRAFT PAPER ONLY FOR DISCUSSION. COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS AND THE ENVIRONMENT (COT) http://www.iacom.org.uk/papers/documents/mut041_000.pdf Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) rats dose of bromobenzene designed to elicit hepatotoxicity in rats liver COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS AND THE ENVIRONMENT http://cot.food.gov.uk/pdfs/TOX-2004-02.PDF Committee on the Medical Effects of Air Pollutants (COMEAP) rats liver toxicity (no definite conclusions drawn in the study). NOTE, DRAFT PAPER ONLY FOR DISCUSSION. COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS AND THE ENVIRONMENT (COT) http://www.advisorybodies.doh.gov.uk/pdfs/cc046.pdf International Agency for Research on Cancer (IARC) rats Study of nephrotoxicity of 2-BP, a metabolite of bromobenzene. kidney http://www.inchem.org/documents/cicads/cicads/cicad66.htm mice and rats 2,4,6-TRIBROMOPHENOL AND OTHER SIMPLE BROMINATED PHENOLS. First draft prepared by Mr P.D. Howe, Dr S. Dobson, and Mr H.M. Malcolm, Centre for Ecology & Hydrology, Monks Wood, United Kingdom. http://www.inchem.org/documents/ehc/ehc/ehc006.htm IPCS INCHEM rats Study of nephrotoxicity of 2-BP, a metabolite of bromobenzene. bronchiolar neurosis kidney REID, W. D., HETT, K. F., HIK, J. M., & KRISHNA, G. (1973) Metabolism and binding of aromatic hydrocarbons in the lung. Am. Rev. Resp. Dis., 107: 539- 551. http://www.inchem.org/documents/cicads/cicads/cicad66.htm mice and rats 2,4,6-TRIBROMOPHENOL AND OTHER SIMPLE BROMINATED PHENOLS. First draft prepared by Mr P.D. Howe, Dr S. Dobson, and Mr H.M. Malcolm, Centre for Ecology & Hydrology, Monks Wood, United Kingdom. http://www.inchem.org/documents/ehc/ehc/ehc006.htm IPCS concise International Chemical Assessment Documents (CICADs) rats hepatotoxicity of bromobenzene and bronchiolar neurosis liver and bronchiolar neurosis Study of nephrotoxicity of 2-BP, a metabolite of kidney bromobenzene. JOLLOW, P. J., MITCHELL, J. R., ZAMPOGLIONE, N., & GILLETTE, J. R. (1974) Bromobenzene-induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology, 11: 151-169. http://www.inchem.org/documents/cicads/cicads/cicad66.htm 2,4,6-TRIBROMOPHENOL AND OTHER SIMPLE BROMINATED PHENOLS. First draft prepared by Mr P.D. Howe, Dr S. Dobson, and Mr H.M. Malcolm, Centre for Ecology & Hydrology, Monks Wood, United Kingdom. Page 2 of 4 EIC proforma bromobenzene.xls28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Bromobenzene CAS Number: 108-86-1 Assessor A: Simon Clennell-Jones (WSP) Assessor B: David Gallagher (ERM) Final review: Panel/SF Joint Expert Committee on Food Additives (JECFA) http://who.int/ipcs/food/jecfa/en/ NR 13/05/2009 Date 19/05/2009 Date 20/05/2009 Date 28/08/2009 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 14/06/2007 13/05/2009 Draft RfD (not to be quoted or cited) 0.006 mg.kg-1.d-1 6 BMDL10 (benchmark dose) 17.8 (adjusted to account for daily exposure) mg/kg/bw/day 3000 10 for interspecies extrapolation, 10 for inter-individual human variability, 10 for database deficiencies and 3 for extrapolation from a sub-chronic to chronic exposure study US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) PRG region 9 http://rais.ornl.gov/tox/unauthorized.shtml 26/07/2001 NA RfD PPRTV 0.024 mg/kg/bw/day 24 low NOAEL 71.4 mg/kg/bw/day (duration adjusted NOAEL) http://www.epa.gov/region09/superfund/pr g/files/04prgtable.pdf Oct-04 18/05/2009 RfD PPRTV 0.02 provisional peer reviewed toxicity value (mg.kg-1.d-1) 20 unknown unknown 3000 10 - Interspecies variation 10 - Sub Chronic to Chronic 10 - Intraspecies variation 3 - Database deficiencies The Risk Assessment Information System http://rais.ornl.gov/cgibin/tox/TOX_selectselect=chem 06/04/2009 18/05/2009 RfD PPRTV 0.02 provisional peer reviewed toxicity value (mg.kg-1.d-1) 20 low NOAEL unknown 3000 unknown Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels http://www.tceq.state.tx.us/remediation/tr rp/trrppcls.html 26/03/2009 20/05/2009 RfD 0.02 mg/kg/bw/day 20 unknown unknown TDI inhal Recommended TDIinhal Units Justification 3.43 μg/kg.bw/day USEPA PPRTV which is also the reference used by PRG region 9 and RAIS. More recent draft US EPA toxicological review for bromobenzene gives higher draft RfC but this has not been used due to DRAFT status. Organisation Last Updated Health criteria type Value Initial Units CLEA units ug.kg-1.d-1 Confidence rating Health and Safety Executive (HSE) http://www.hse.gov.uk/ 11/05/2009 12/05/2009 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 14/06/2007 13/05/2009 Draft RfC 0.06 mg.m-3 17.14 BMCL10HEC (benchmark concentration) Basis Value Units UF UF description 63 mg/m3 1000 10- database deficiencies 10-Interindividual variation 3- Interspecies variation 3- Sub Chronic to Chronic US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) PRG region 9 http://rais.ornl.gov/tox/unauthorized.shtml 26/07/2001 NA RfC PPRTV 0.012 mg/m 3 3.43 Low NOAEL 34.5 mg/m3 (duration adjusted NOAEL) http://www.epa.gov/region09/superfund/pr g/files/04prgtable.pdf Oct-04 18/05/2009 RfC PPRTV 0.0029 provisional peer reviewed toxicity value (mg.kg-1.d-1) 2.9 unknown unknown 3000 3 - Interspecies variation 10 - Sub Chronic to Chronic 10 - Interindividual variation 10 - Database deficiencies The Risk Assessment Information System http://rais.ornl.gov/cgibin/tox/TOX_selectselect=chem 06/04/2009 18/05/2009 RfC PPRTV 0.01 provisional peer reviewed toxicity value (mg.m-3) 2.86 low NOAEL unknown 3000 unknown Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels http://www.tceq.state.tx.us/remediation/tr rp/trrppcls.html 26/03/2009 20/05/2009 RfC 0.01 mg/m 3 2.86 unknown unknown Page 3 of 4 EIC proforma bromobenzene.xls28/08/2009
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1,3,5-Trimethylbenzene CAS 108-67-8
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