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Bromobenzene
TDI oral
Organisation
Study type Description Target organ/Critical Effect Reference Web link
Food Standards Agency (FSA)
rats
Dosing of bromobenzene to give rise to overt
liver toxicity.
liver toxicity
Hiejne WHM et al Toxicogenomics of bromobenzene hepatotoxicity:
combined transcriptomics and proteomics approach. Biochemical
Pharmacology, 65, 857-875, 2003.
http://cot.food.gov.uk/pdfs/TOX-2004-02annexes.pdf
Committee on the Carcinogenicity of
Chemicals in Food, Consumer Products and
the Environment (COC)
rats
liver toxicity (no definite conclusions
drawn in the study). NOTE, DRAFT PAPER
ONLY FOR DISCUSSION.
COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS
AND THE ENVIRONMENT (COT)
http://www.iacoc.org.uk/papers/documents/cc046.pdf
Committee on the Mutagenicity of
Chemicals in Food, Consumer Products and
the Environment (COM)
rats
liver toxicity (no definite conclusions
drawn in the study). NOTE, DRAFT PAPER
ONLY FOR DISCUSSION.
COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS
AND THE ENVIRONMENT (COT)
http://www.iacom.org.uk/papers/documents/mut041_000.pdf
Committee on the Toxicity of Chemicals in
Food, Consumer Products and the
Environment (COT)
rats
dose of bromobenzene designed to elicit
hepatotoxicity in rats
liver
COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS
AND THE ENVIRONMENT
http://cot.food.gov.uk/pdfs/TOX-2004-02.PDF
Committee on the Medical Effects of Air
Pollutants (COMEAP)
rats
liver toxicity (no definite conclusions
drawn in the study). NOTE, DRAFT PAPER
ONLY FOR DISCUSSION.
COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD CONSUMER PRODUCTS
AND THE ENVIRONMENT (COT)
http://www.advisorybodies.doh.gov.uk/pdfs/cc046.pdf
International Agency for Research on
Cancer (IARC)
rats
Study of nephrotoxicity of 2-BP, a metabolite of
bromobenzene.
kidney
http://www.inchem.org/documents/cicads/cicads/cicad66.htm
mice and rats
2,4,6-TRIBROMOPHENOL AND OTHER SIMPLE BROMINATED PHENOLS. First
draft prepared by Mr P.D. Howe, Dr S. Dobson, and Mr H.M. Malcolm,
Centre for Ecology & Hydrology, Monks Wood, United Kingdom.
http://www.inchem.org/documents/ehc/ehc/ehc006.htm
IPCS INCHEM
rats
Study of nephrotoxicity of 2-BP, a metabolite of
bromobenzene.
bronchiolar neurosis
kidney
REID, W. D., HETT, K. F., HIK, J. M., & KRISHNA, G. (1973) Metabolism and
binding of aromatic hydrocarbons in the lung. Am. Rev. Resp. Dis., 107: 539-
551.
http://www.inchem.org/documents/cicads/cicads/cicad66.htm
mice and rats
2,4,6-TRIBROMOPHENOL AND OTHER SIMPLE BROMINATED PHENOLS. First
draft prepared by Mr P.D. Howe, Dr S. Dobson, and Mr H.M. Malcolm,
Centre for Ecology & Hydrology, Monks Wood, United Kingdom.
http://www.inchem.org/documents/ehc/ehc/ehc006.htm
IPCS concise International Chemical
Assessment Documents (CICADs)
rats
hepatotoxicity of bromobenzene and
bronchiolar neurosis
liver and bronchiolar neurosis
Study of nephrotoxicity of 2-BP, a metabolite of kidney
bromobenzene.
JOLLOW, P. J., MITCHELL, J. R., ZAMPOGLIONE, N., & GILLETTE, J. R. (1974)
Bromobenzene-induced liver necrosis: protective role of glutathione and
evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
Pharmacology, 11: 151-169.
http://www.inchem.org/documents/cicads/cicads/cicad66.htm
2,4,6-TRIBROMOPHENOL AND OTHER SIMPLE BROMINATED PHENOLS. First
draft prepared by Mr P.D. Howe, Dr S. Dobson, and Mr H.M. Malcolm,
Centre for Ecology & Hydrology, Monks Wood, United Kingdom.
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EIC proforma bromobenzene.xls28/08/2009