Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Bis ethylhexyl phthalate,<br />
di(2 ethylhexyl)phthalate or DEHP<br />
ID inhal<br />
Organisation<br />
Study type Description Response Reference Web link<br />
<strong>Health</strong> Protection Agency (HPA)<br />
Phthalates (Diisononylphthalate and Di(2-ethylhexyl)phthalate) Incident<br />
management, <strong>Health</strong> Protection Agency 2008<br />
http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1194947324949<br />
<strong>Health</strong> and Safety Executive (HSE)<br />
http://www.hse.gov.uk/aboutus/meetings/hscarchive/2004/091104/c06c.pdf<br />
Committee on the Carcinogenicity of<br />
Chemicals in Food, Consumer Products and<br />
the Environment (COC)<br />
CC/01/25<br />
http://www.iacoc.org.uk/papers/documents/mindurcarcstudy.PDF<br />
COMMITTEE ON CARCINOGENICITY OF CHEMICALS IN FOOD<br />
CONSUMER PRODUCTS AND THE ENVIRONMENT<br />
THE MINIMUM DURATION OF CARCINOGENICITY STUDIES IN RATS, November<br />
2001<br />
European Chemicals Bureau (ECB)<br />
Based on the overall evaluation of the studies on<br />
mutagenicity (see Section 4.1.2.8) DEHP and<br />
its major metabolites can be regarded as non-genotoxic<br />
agents.<br />
European Union <strong>Risk</strong> <strong>Assessment</strong> Report Volume 80 , 2008<br />
http://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-<br />
Chemicals/RISK_ASSESSMENT/REPORT/dehpreport042.pdf<br />
International Agency <strong>for</strong> Research on Cancer<br />
(IARC)<br />
Di(2-ethylhexyl) phthalate is not classifiable as to its<br />
carcinogenicity to humans (Group 3) .<br />
International Agency <strong>for</strong> Research on Cancer (IARC) - Summaries &<br />
Evaluations<br />
DI(2-ETHYLHEXYL) PHTHALATE<br />
(Group 3)<br />
VOL.: 77 (2000) (p. 41)<br />
http://www.inchem.org/documents/iarc/vol77/77-01.html<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and<br />
the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
Baars et al states that there is no indication that DEHP is a<br />
geotaxis carcinogen.<br />
re-evaluation of maximum permissible levels By Baars et al RIVM 711701025/2001http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf (Baars et al)<br />
<strong>Health</strong> Canada Toxicological Values<br />
"The weight of evidence also indicates that the metabolites<br />
of bis(2-ethylhexyl) phthalate, mono(2-ethylhexyl) phthalate,<br />
and 2-ethylhexanol, are not geotaxis."<br />
Bis(2-ethylhexyl) Phthalate - PLS1<br />
http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1-<br />
lsp1/bis_2_ethylhexyl/bis_2_ethylhexyl_3-eng.php<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATDSR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
No studies located regarding genotoxic effects in humans .<br />
DEHP has been extensively tested in short-term genotoxicity<br />
assays with predominantly negative or false-positive results.<br />
Weight of evidence indicates that DEHP best characterized as<br />
an epigenetic toxicant.<br />
Toxicological Profile <strong>for</strong> Di(2-ethylhexyl)phthalate (DEHP) September 2002 including<br />
Reference: David RM, Moore MR, Finney DC, et al. 2000a. Chronic toxicity of<br />
di(2-ethylhexyl)phthalate in rats. Toxicol Sci 55:433-443.<br />
http://www.atsdr.cdc.gov/toxprofiles/tp9.pdf (&<br />
http://www.atsdr.cdc.gov/mrls/index.html <strong>for</strong> MRLs)<br />
USEPA <strong>Health</strong> Advisors<br />
Reference to IRIS<br />
Page 10 of 10<br />
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