Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Bis ethylhexyl phthalate,<br />
di(2 ethylhexyl)phthalate or DEHP<br />
CAS Number: 117-81-7 Assessor A: Barry Mitcheson, Assessor B: Charlotte Clark, Final review: Panel/SF<br />
Enviros<br />
Hyder<br />
Date 05/05/2009 Date 06/05/2009 Date 26/08/2009<br />
ID oral Recommended ID oral Units<br />
Justification<br />
n/a<br />
Weight of evidence indicates not carcinogenic.<br />
Organisation Last Updated Non threshold<br />
effects<br />
Committee on the Carcinogenicity of http://www.advisorybodies.doh.gov.uk/coc/i<br />
06/04/2009 No dose data<br />
Chemicals in Food, Consumer Products and ndex.htm<br />
indentified.<br />
the Environment (COC)<br />
Chemicals <strong>for</strong> which a<br />
tumorigenic<br />
effect was first<br />
observed between 53<br />
and 80<br />
week in rats and/or<br />
mice.<br />
European Chemicals Bureau (ECB) http://ecb.jrc.it/ Date of Last Literature<br />
Search : 2005<br />
Review of report by MS<br />
Technical Experts<br />
finalised: September<br />
2005<br />
Final report: 2008<br />
07/04/2009<br />
Basis <strong>Health</strong> criteria type Value Units Confidence rating Basis<br />
International Agency <strong>for</strong> Research on Cancer<br />
(IARC)<br />
http://inchem.org/pages/iarc.html 2000 07/04/2009<br />
ICPS Environmental <strong>Health</strong> <strong>Criteria</strong> (EHC)<br />
Monographs<br />
http://inchem.org/pages/ehc.html 07/04/2009<br />
WHO Guidelines <strong>for</strong> drinking water Quality<br />
http://www.who.int/water_sanitation_health<br />
/dwq/guidelines/en<br />
2006 08/04/2009 TDI but relates to<br />
carcinomas and<br />
hepatocarcinogenicit<br />
y<br />
25 ug/kg of body<br />
weight <strong>for</strong> DEHP, based<br />
on WHO DWS of 8ug/l.<br />
Data given as<br />
ug/l 25 Low Based on a NOAEL 2.5 mg/kg bw/d NOAEL mg/kg of body<br />
<strong>for</strong> peroxisomal<br />
proliferation in the<br />
liver in rats,<br />
weight per day<br />
100<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and<br />
the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
http://www.rivm.nl/en/ 2001 08/04/2009<br />
<strong>Health</strong> Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html 19/04/2007 08/04/2009<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATDSR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
http://www.atsdr.cdc.gov/<br />
14/01/2009 <strong>for</strong> MRL<br />
page (And report June<br />
2002)<br />
08/04/2009<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
http://www.epa.gov/waterscience/criteria/dr<br />
inking<br />
02/01/1993 08/04/2009 Oral Slope Factor 1.4E-2/mg/kg/day 0.000714286<br />
mg/kgbw/day<br />
0.714286 Medium<br />
Page 7 of 10<br />
EIC_pro<strong>for</strong>ma_bis_ethylhexyl_phthalate.xls26/08/2009
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