Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948<br />
Bis ethylhexyl phthalate,<br />
di(2 ethylhexyl)phthalate or DEHP<br />
TDI inhal<br />
Organisation<br />
Study type Description Response Reference Web link<br />
<strong>Health</strong> Protection Agency (HPA)<br />
Page on exposure standards details no drinking water<br />
standard no soil standard or air standard WEL of LTEL(8 hour<br />
reference period): 0.3 ppm (5 mg m-3 )<br />
Phthalates (Diisononylphthalate and Di(2-ethylhexyl)phthalate) Incident<br />
management, <strong>Health</strong> Protection Agency 2008<br />
http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1194947324949<br />
<strong>Health</strong> and Safety Executive (HSE)<br />
Data review<br />
HSC/04/06 Annex C All three listed. WEL 5mg/m3 and STEL<br />
10mg/m3. <strong>Risk</strong> Phrases refer to R60 and R61 (harm fertility<br />
and harm the unborn child).<br />
EH40/2005 Table 1: List of approved workplace exposure limits (as<br />
consolidated with amendments October 2007)<br />
http://www.hse.gov.uk/coshh/table1.pdf<br />
European Chemicals Bureau (ECB)<br />
See Description<br />
Rat, F-344, males and females Diet, 2 years; GLP, comparable RDT (effect on Kidneys)<br />
to guideline study Both sexes:<br />
weight More severe kidney lesions were observed at the<br />
highest dose level<br />
European Union <strong>Risk</strong> <strong>Assessment</strong> Report Volume 80 , 2008<br />
http://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-<br />
Chemicals/RISK_ASSESSMENT/REPORT/dehpreport042.pdf<br />
See Description<br />
Rat, Sprague- Dawley, males and females Diet, 3- generation Testes<br />
guideline study Testicular toxicity as well as Developmental<br />
toxicity:increased incidences of small testes, epididymes, and<br />
seminal vesicles, as well as cases of minimal testes atrophy.<br />
The toxicity was aggravated by exposure during the<br />
gestational/pup-period<br />
See Description<br />
Mouse, CD-1, males and females Diet, continuous breeding<br />
study; GLP, comparable to guideline study Fertility <br />
dependent <br />
live pups; crossover matings showed that both sexes were<br />
affected<br />
Fertility<br />
See Description<br />
Rat, Sprague-Dawley, males and females Diet, 3- generation<br />
guideline study Testicular toxicity as well as Developmental<br />
toxicity: increased incidences of small testes, epididymes,<br />
and seminal vesicles, as well as cases of minimal testes<br />
atrophy. The toxicity was aggravated by exposure during the<br />
gestational/pup-period<br />
Developmental effects on foetus<br />
IPCS INCHEM<br />
WHO Guidelines <strong>for</strong> drinking water Quality<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and<br />
the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATDSR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
Stated value - source unknown The regulations <strong>for</strong> indoor air pollution in Japan: A public health perspective, http://www.euro.who.int/Document/E87878_pt3.pdf<br />
Kenichi Azuma<br />
Baars et al states that inhalation not considered relevant due<br />
re-evaluation of maximum permissible levels By Baars et al RIVM 711701025/2001 http://www.rivm.nl/bibliotheek/rapporten/609021064.pdf &<br />
to low volatility. The dust paper uses the oral EFSA value<br />
http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf (Baars et al)<br />
given above<br />
rats systemic toxicity in rats Hassauer M et al, (1993) Basisdate Toxikologie fur umweltrelevante Stoffe zur<br />
Gefahrenbeuteilung bei Altlasten, Germany<br />
No inhalation MRLs were derived <strong>for</strong> DEHP due to<br />
Reversible effects in the lungs and liver following exposure Toxicological Profile <strong>for</strong> Di(2-ethylhexyl)phthalate (DEHP) September 2002 including http://www.atsdr.cdc.gov/toxprofiles/tp9.pdf (&<br />
inadequate data <strong>for</strong> this route of exposure. Inhalation<br />
database <strong>for</strong> DEHP is essentially limited to two studies in<br />
rats. Systemic effects (liver weight and lung function )<br />
intermediate study only . LOAEL = 100mg/m3, NOAEL =<br />
50mg/m3.<br />
<strong>for</strong> 28 days and no evidence<br />
<strong>for</strong> reproductive or developmental toxicity (Klimisch et al.<br />
1991; Merkle et al. 1988).<br />
Reference: David RM, Moore MR, Finney DC, et al. 2000a. Chronic toxicity of di(2-<br />
ethylhexyl)phthalate in rats. Toxicol Sci 55:433-443.<br />
http://www.atsdr.cdc.gov/mrls/index.html <strong>for</strong> MRLs)<br />
USEPA <strong>Health</strong> Advisors<br />
Toxicology Data Network (Toxnet)<br />
Occupational <strong>Health</strong> Value<br />
Occupational <strong>Health</strong> Value<br />
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/rdbs+hsdb:@term+@rn+117-<br />
81-7<br />
Occupational <strong>Health</strong> Value<br />
Page 6 of 10<br />
EIC_pro<strong>for</strong>ma_bis_ethylhexyl_phthalate.xls26/08/2009
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