Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Bis ethylhexyl phthalate,
di(2 ethylhexyl)phthalate or DEHP
TDI inhal
CAS Number: 117-81-7 Assessor A: Barry Mitcheson, Assessor B: Charlotte Clark, Final review: Panel/SF
Enviros
Hyder
Date 05/05/2009 Date 06/05/2009 Date 26/08/2009
Recommended TDI Units
Justification
inhal
ug.kg-1.d-1 Insufficient data with sufficient detail on derivation to derive
Organisation Last Updated Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
Health Protection Agency (HPA) http://www.hpa.org.uk/ 11-Sep-08 31/03/2009
Confidence rating Basis Value Units UF UF description
Health and Safety Executive (HSE) http://www.hse.gov.uk/ 06/04/2009 WEL & STEL 8 hrs - 5, 15 mins - 10 mg.m-3
European Chemicals Bureau (ECB) http://ecb.jrc.it/ Date of Last Literature
Search : 2005
Review of report by MS
Technical Experts
finalised: September
2005
Final report: 2008
07/04/2009 Data for Oral also
applied to dermal an
inhalation in risk
assessment. NOAEL
for kidneys
(14.5mg/kgbw/day),
testicular
(4.8mg/kgbw/day,rep
roduction
(10mg/kgbw/day)
development
4.8mg/kgbw/day) and
added a MOS of 30 to
250 for adults to
babies and 100 for
children
0.145 mg/kgbw/day 145 Not given Moore
(1996) with
adjustment for
50% absorption
0.048 mg/kgbw/day 48 Not given Wolfe et al. (2003)
Oral exposure
0.1 mg/kgbw/day 100 Not given Lamb et al.
(1987) with
adjustment for
50% absorption
14.5 NOAEL
mg/kgbw/day
4.8 NOAEL
mg/kgbw/day
10 NOAEL
mg/kgbw/day
100
An assessment factor of 10 is used for
potential species differences.
Assessment factors of 3 and 10 are
used for potential
intraspecies differences for the worker
and general population, respectively.
Giving Margin of Safety of 30
(commercial) to 100 for children. We
have used the 100 figure.
For infants of 3- 12 month a factor of
20 and for