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Biphenyl CAS 91-52-4 Assessor A: Y Macklin, AMEC Assessor B: K Privett, Hydrock Final review: Panel/SF
Date 25/03/2009 Date 08/05/2009 Date 26/08/2009
MDI
Recommended
MDIoral Units
4.49 ug day-1
Justification: Sum of dietary and water intake from CICAD document. Most relevant data in the absence of any UK data.
Organisation Date Media Value Units Description Reference Web link
IPCS Concise International
Chemical Assessment
Documents (CICADs)
06/04/2009 Drinking water 0.01 μg day-1 In measurements conducted in the 1970s, levels of
biphenyl in tap-water were usually below 5 ng/litre.
Multiply by 2l per day for adult consumption. Convert
from ng/l to μg/l divide by 1,000.
http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf http://inchem.org/pages/cicads.html
IPCS Concise International
Chemical Assessment
Documents (CICADs)
Joint Expert Committee on Food
Additives (JECFA)
Joint FAO WHO Meeting on
Pesticide Residues (JMPR)
Health Canada Toxicological
Reference Values
06/04/2009 Food 4.48 μg day-1 An average intake of 64 ng biphenyl/kg body weight
per day from food was calculated based upon the
consumption of foodstuffs in Finland. Original units
(64 ng/kg bw/day) multiplied by 70kg to convert from
ng/kg bw/day to ng/day. Convert from ng/day to
μg/day divide by 1000.
http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf http://inchem.org/pages/cicads.html
28/01/2006 Food additive No safety concern at current levels of intake when TRS 928-JECFA 63/73
http://jecfa.ilsi.org/evaluation.cfmchemical
used as a flavouring agent.
FAS 54-JECFA 63/291
=BIPHENYL&keyword=BIPHENYL
06/04/2009 Food 100 ppm Legal limit in citrus fruit for UK. http://www.inchem.org/documents/jmpr/jmpmono/v66apr07.htm www.who.int/ipcs/food/jmpr/en/
http://www.hc-sc.gc.ca/index-eng.php
Toxicological Data Network
(TOXNET)
MDI
23/08/2005 Drinking water DWS
MN 300ug/l
FL 0.5ug/l
HSDB entry
Recommended
Justification: in the absence of any UK data, CICAD data for Finland used.
MDIinh
Units
0.524 ug day-1
Organisation Date Media Value Units Description Reference Web link
IPCS Concise International
Chemical Assessment
Documents (CICADs)
06/04/2009 Ambient air 0.524 μg day-1 In 1985, concentrations of biphenyl in the air of an
industrialized city in Finland ranged from 1.7 to 26.2
ng/m 3 . Upper bound estimate used. Multiply by 20m 3
to allow for adult inhalation. Convert from ng/day to
μg/day divide by 1,000.
http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf http://inchem.org/pages/cicads.html
Health Canada Toxicological
Reference Values
06/04/2009 Ambient air 3.50E-05 μg day-1 Table 1: Upper-bounding estimates of daily intake of
biphenyl by the general population of Canada. Values
for 0-6 months and 6months- 4 years added.
06/04/2009 Food, drinking water 1.5 μg/kg bw/day The upper-bounding estimate of intake for the most http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/biphenyl-biphenyle/biphenyl-eng.pdf
bw per day for the general population.
http://toxnet.nlm.nih.gov/cgibin/sis/search/f./temp/~9mdbn6:1
http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/biphenyl-biphenyle/biphenyl-eng.pdf
www.hc-sc.ga.ca/index_e.html
Toxicological Data Network
(TOXNET)
06/04/2009 Ambient air 2 μg day-1 In ambient air, typical concentrations of biphenyl range http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~RQGBrI:1
from 1 to 100 ng/m 3 . Upper end of range used.
Convert to μg day multiply by 20m3 and divide by
1000. No information provided on date or source of
data.
http://toxnet.nlm.nih.gov/
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