Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Biphenyl TDI inhal Organisation UF description Study type Description Response Reference Web link IPCS concise International Chemical Assessment Documents (CICADs) Health Canada Toxicological Values Subchronic Lowest-Observed-Effect Concentration (LOEC) for non-neoplastic effects (mortality and respiratory irritation) (5 mg/m3) with the upperbounding estimate of indoor air concentration http://inchem.org/documents/cicads/cicads/cicad06.htm#SubSectionNumb er:8.3.2 http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/biphenylbiphenyle/evaluation-eng.php USEPA Acute Guideline Levels (AEGLs) A total uncertainty factor of 10 was applied for the AEGL-2 values with 3 for interspecies variability because the mouse was the most sensitive species and had clinical signs similar to other species; and 3 for intraspecies variability. Chronic-animal chronic inhalation study in mice exposed to 316 mg/m 3 (50 ppm) biphenyl 7 hours/day, 5 days/week for 13 weeks. The report states some adverse clinical signs were observed but they are not stated. Upon histopathological examination, tracheal hyperplasia was recorded. Cannon Laboratories, Inc. 1977. Final report: 90-day inhalation toxicity study hhttp://epa.gov/oppt/aegl/pubs/rest147.htm and of biphenyl (99+% purity) in CD-1 mice. Sponsored by Sun Company Lab. EPA http://epa.gov/oppt/aegl/pubs/biphenyl_interim_11_2007.v1.pdf.pdf Doc. No. 878213532; Fiche No. OTS0206401 USEPA Integrated Risk Information System (IRIS) Toxicology Data Network (Toxnet) Based on NIOSH and OSHA occupational standards ID oral Organisation Study type Description Response Reference Web link ID inhal Organisation Study type Description Response Reference Web link Page 4 of 4 EIC proforma biphenyl.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Biphenyl CAS 91-52-4 Assessor A: Y Macklin, AMEC Assessor B: K Privett, Hydrock Final review: Panel/SF Date 25/03/2009 Date 08/05/2009 Date 26/08/2009 MDI Recommended MDIoral Units 4.49 ug day-1 Justification: Sum of dietary and water intake from CICAD document. Most relevant data in the absence of any UK data. Organisation Date Media Value Units Description Reference Web link IPCS Concise International Chemical Assessment Documents (CICADs) 06/04/2009 Drinking water 0.01 μg day-1 In measurements conducted in the 1970s, levels of biphenyl in tap-water were usually below 5 ng/litre. Multiply by 2l per day for adult consumption. Convert from ng/l to μg/l divide by 1,000. http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf http://inchem.org/pages/cicads.html IPCS Concise International Chemical Assessment Documents (CICADs) Joint Expert Committee on Food Additives (JECFA) Joint FAO WHO Meeting on Pesticide Residues (JMPR) Health Canada Toxicological Reference Values 06/04/2009 Food 4.48 μg day-1 An average intake of 64 ng biphenyl/kg body weight per day from food was calculated based upon the consumption of foodstuffs in Finland. Original units (64 ng/kg bw/day) multiplied by 70kg to convert from ng/kg bw/day to ng/day. Convert from ng/day to μg/day divide by 1000. http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf http://inchem.org/pages/cicads.html 28/01/2006 Food additive No safety concern at current levels of intake when TRS 928-JECFA 63/73 http://jecfa.ilsi.org/evaluation.cfmchemical used as a flavouring agent. FAS 54-JECFA 63/291 =BIPHENYL&keyword=BIPHENYL 06/04/2009 Food 100 ppm Legal limit in citrus fruit for UK. http://www.inchem.org/documents/jmpr/jmpmono/v66apr07.htm www.who.int/ipcs/food/jmpr/en/ http://www.hc-sc.gc.ca/index-eng.php Toxicological Data Network (TOXNET) MDI 23/08/2005 Drinking water DWS MN 300ug/l FL 0.5ug/l HSDB entry Recommended Justification: in the absence of any UK data, CICAD data for Finland used. MDIinh Units 0.524 ug day-1 Organisation Date Media Value Units Description Reference Web link IPCS Concise International Chemical Assessment Documents (CICADs) 06/04/2009 Ambient air 0.524 μg day-1 In 1985, concentrations of biphenyl in the air of an industrialized city in Finland ranged from 1.7 to 26.2 ng/m 3 . Upper bound estimate used. Multiply by 20m 3 to allow for adult inhalation. Convert from ng/day to μg/day divide by 1,000. http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf http://inchem.org/pages/cicads.html Health Canada Toxicological Reference Values 06/04/2009 Ambient air 3.50E-05 μg day-1 Table 1: Upper-bounding estimates of daily intake of biphenyl by the general population of Canada. Values for 0-6 months and 6months- 4 years added. 06/04/2009 Food, drinking water 1.5 μg/kg bw/day The upper-bounding estimate of intake for the most http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/biphenyl-biphenyle/biphenyl-eng.pdf bw per day for the general population. http://toxnet.nlm.nih.gov/cgibin/sis/search/f./temp/~9mdbn6:1 http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/biphenyl-biphenyle/biphenyl-eng.pdf www.hc-sc.ga.ca/index_e.html Toxicological Data Network (TOXNET) 06/04/2009 Ambient air 2 μg day-1 In ambient air, typical concentrations of biphenyl range http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~RQGBrI:1 from 1 to 100 ng/m 3 . Upper end of range used. Convert to μg day multiply by 20m3 and divide by 1000. No information provided on date or source of data. http://toxnet.nlm.nih.gov/ Page 1 of 1 EIC proforma biphenyl.xls 26/08/2009
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