Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

More documents

Recommendations

Info

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Biphenyl TDI oral Organisation UF description Study type Description Target organ/Critical Effect Reference Web link IPCS concise International Chemical Assessment Documents (CICADs) x10 for interspecies variation, x10 for intraspecies variation, x10 for extrapolation from a LOEL to a NOEL. Animal Based on the development effects on the blood of rats administered diets containing biphenyl for 2 years. WHO (1999) Concise International Chemical Assessment Document 6. Biphenyl. http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf JECFA 2 Long term study in rats use of dietary levels of 0.01%, 0.1% and 1% diphenyl for a 2-year period. Joint FAO/WHO Expert Committee on Food Additives (1964) Specifications for identify and purity and toxicological evaluation of some antimicrobials and antioxidants http://www.inchem.org/documents/jecfa/jecmono/v38aje15.htm JMPR 2 Health Canada Toxicological Values not given not given not given Joint Meeting of the FAO Working Party and the WHO Expert Committee on Pesticide Residues (1967) EVALUATION OF SOME PESTICIDE RESIDUES IN FOOD not given Animal-chronic Lowest oral (diet) non-neoplastic LOEL (rat) = 38 mg/kg-bw per day: increased serum enzyme and blood urea nitrogen levels (2-year study). (Japan Bioassay Research Center,1996; Umeda et al., 2002) in Health Canada (2005) State of the Science Report for a Screening Health Assessment- 1,1- Biphenyl http://www.inchem.org/documents/jmpr/jmpmono/v66apr07.htm http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/biphenyl-biphenyle/biphenyl-eng.pdf USEPA Integrated Risk Information System (IRIS) UF — Factors of 10 each for Rat Chronic Oral interspecies conversion and for Study protection of sensitive human subpopulations were applied to the NOAEL of 50 mg/kg/day. An additional factor of 10 was applied to account for intraspecies variability demonstrated by uncertainty in the threshold suggested by the data in the critical study. 15 weanling albino rats of each sex were placed Kidney damage in each of 8 experimental groups: 0.0, 0.001, 0.005, 0.01, 0.05, 0.10, 0.50, and 1.0% biphenyl in the diet. Dietary levels of 0.5% biphenyl and greater were associated with kidney damage, reduced haemoglobin levels, decreased food intake, and decreased longevity. One animal in each of the lower dose groups and control group had detectable blood in the renal pelvis. A supporting unpublished work (SRI, 1960) was cited in which a NOAEL of 0.1% biphenyl in the diet was found in both a subchronic rat feeding study and a three- generation rat reproduction study. Ambrose, A.M., A.N. Booth, F. DeEds and A.J. Cox, Jr. 1960. A toxicological study of biphenyl, a citrus fungistat. Food Res. 25: 328-336 http://www.epa.gov/NCEA/iris/subst/0013.htm Page 2 of 4 EIC proforma biphenyl.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 TDI inhal Biphenyl CAS Number: 92-52-4 Assessor A: Y Macklin, AMEC Assessor B: K Privett, Final review: Panel/SF Hydrock Date 25/03/2009 Date 08/05/2009 Date 26/08/2009 Recommended TDIinhal Units Justification Insufficient data with sufficient detail to derive HCV Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF 1.d-1 IPCS concise International Chemical http://inchem.org/pages/cicads.html unknown 26/03/2009 OEL 1.3 mg/m3 Assessment Documents (CICADs) Health Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html 02/07/2008 27/03/2009 LOEC 5 mg/m3 USEPA Acute Guideline Levels (AEGLs) http://epa.gov/oppt/aegl/pubs/chemlist.htm 13/02/2009 27/03/2009 OEL (AEGL-2) 28 (8 Hour) mg/m3 Derived from chronic mouse study 90- not implicitly stated USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 10/01/2008 27/03/2009 The health effects data for biphenyl were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for derivation of an inhalation RfC Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ unknown 27/03/2009 OEL 8-hrTWA 1 mg/m3 Not given. OSHA, ACGIH, NIOSH ID oral Recommended IDoral Units n/a Justification Classification D (IRIS) not classifiable as to human carcinogenicity. No human data and inadequate studies in mice and rats. Results of genotoxicity tests are generally negative. Organisation Web Link Last Updated Date Web Checked Non threshold effects Basis Health criteria type Value Units Confidence rating Basis ID inhal Recommended IDinhal Units n/a Justification Classification D (IRIS) not classifiable as to human carcinogenicity. No human data and inadequate studies in mice and rats. Results of genotoxicity tests are generally negative. Organisation Web Link Last Updated Date Web Checked Non threshold effects Basis Health criteria type Value Units Confidence rating Basis Page 3 of 4 EIC proforma biphenyl.xls 26/08/2009
Page 1 and 2:
www.esdat.net Esdat Environmental D
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98: www.esdat.net Esdat Environmental D
Page 103 and 104: 1,3,5-Trimethylbenzene CAS 108-67-8
Page 147: www.esdat.net Esdat Environmental D
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321:
show all

Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

Create successful ePaper yourself

Delete template?

Save as template?