Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948
Biphenyl
TDI oral
Organisation
UF description Study type Description Target organ/Critical Effect Reference Web link
IPCS concise International Chemical
Assessment Documents (CICADs)
x10 for interspecies variation, x10 for
intraspecies variation, x10 for
extrapolation from a LOEL to a NOEL.
Animal
Based on the development effects on the blood
of rats administered diets containing biphenyl
for 2 years.
WHO (1999) Concise International Chemical Assessment Document 6.
Biphenyl.
http://www.who.int/ipcs/publications/cicad/en/cicad06.pdf
JECFA 2
Long term study in rats use of dietary levels of
0.01%, 0.1% and 1% diphenyl for a 2-year
period.
Joint FAO/WHO Expert Committee on Food Additives (1964) Specifications
for identify and purity and toxicological evaluation of some antimicrobials
and antioxidants
http://www.inchem.org/documents/jecfa/jecmono/v38aje15.htm
JMPR 2
Health Canada Toxicological Values
not given not given not given Joint Meeting of the FAO Working Party and the WHO Expert Committee on
Pesticide Residues (1967) EVALUATION OF SOME PESTICIDE RESIDUES IN
FOOD
not given Animal-chronic Lowest oral (diet) non-neoplastic LOEL (rat) = 38
mg/kg-bw per day: increased serum enzyme
and blood urea nitrogen levels (2-year study).
(Japan Bioassay Research Center,1996; Umeda et al., 2002) in Health Canada
(2005) State of the Science Report for a Screening Health Assessment- 1,1-
Biphenyl
http://www.inchem.org/documents/jmpr/jmpmono/v66apr07.htm
http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/biphenyl-biphenyle/biphenyl-eng.pdf
USEPA Integrated Risk Information System
(IRIS)
UF — Factors of 10 each for
Rat Chronic Oral
interspecies conversion and for Study
protection of sensitive human
subpopulations were applied to the
NOAEL of 50 mg/kg/day. An
additional factor of 10 was applied to
account for intraspecies variability
demonstrated by uncertainty in the
threshold suggested by the data in the
critical study.
15 weanling albino rats of each sex were placed Kidney damage
in each of 8 experimental groups: 0.0, 0.001,
0.005, 0.01, 0.05, 0.10, 0.50, and 1.0% biphenyl
in the diet. Dietary levels of 0.5% biphenyl and
greater were associated with kidney damage,
reduced haemoglobin levels, decreased food
intake, and decreased longevity. One animal in
each of the lower dose groups and control
group had detectable blood in the renal pelvis. A
supporting unpublished work (SRI, 1960) was
cited in which a NOAEL of 0.1% biphenyl in the
diet was found in both a subchronic rat feeding
study and a three- generation rat reproduction
study.
Ambrose, A.M., A.N. Booth, F. DeEds and A.J. Cox, Jr. 1960. A toxicological
study of biphenyl, a citrus fungistat. Food Res. 25: 328-336
http://www.epa.gov/NCEA/iris/subst/0013.htm
Page 2 of 4 EIC proforma biphenyl.xls 26/08/2009