Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Biphenyl CAS Number: 92-52-4 Assessor A: Y Macklin, AMEC Assessor B: K Privett, Final review: Panel/SF
Hydrock
Date 25/03/2009 Date 08/05/2009 Date 26/08/2009
Oral Dermal Inhalation Combine Oral
and Inhalation
TDIs
Justification
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
Yes Yes Yes
No No No
No No No
No No No
NR
Classification D (IRIS) not classifiable as to human
carcinogenicity.
Classification D (IRIS) not classifiable as to human
carcinogenicity. Insufficient data with sufficient detail
to derive inhalation HCV. Use route-to-route
extrapolation from oral.
TDI oral
Recommended
TDIoral
Units
38 ug.kg-1.d-1
Justification
CICAD value taken even though provisional status, and is more recent than IRIS value
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF
1.d-1
IPCS concise International Chemical
Assessment Documents (CICADs)
http://inchem.org/pages/cicads.html unknown 26/03/2009 Provisional TDI 0.038 mg/kg bw/day 38 Provisional LOEL 38 mg/kg bw/day 1000
JECFA 2 http://inchem.org/pages/jecfa.html unknown 27/03/2009 TDI 0.05 mg/kg bw/day 50 Acceptable daily
intake for a man
(unconditional
acceptance).
JMPR 2 http://inchem.org/pages/jmpr.html unknown 27/03/2009 TDI 0.125 mg/kg bw/day 125 Acceptable daily
intake for a 60kg
person.
Health Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html 02/07/2008 27/03/2009 MOE 25000 Based on a LOEL
of 38 mg/kg
bw/day and a
daily intake of
biphenyl of 1.5
mg/kg bw/day
0.05 mg/kg bw/day not given
38 mg/kg bw/day
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ 10/01/2008 27/03/2009 RfD 5.00E-02 mg/kg bw/day 50 NOAEL 50 mg/kg bw/day 100
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