Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 4-Methylphenol TDI oral Organisation Description Target organ/Critical Effect Reference Web link IPCS INCHEM Based on the results of subchronic studies, although no further information provided Not provided Not provided http://inchem.org/documents/ehc/ehc/ehc168.htm Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels 90 day subchronic toxicity study (US EPA, CNS, Weight loss, neurological events 1986), rats gavaged daily with p-cresol. 90 day neurotoxicity study (US EPA, 1987), rats gavaged daily with o-cresol Groups of female mice were administered m/pcresol (60% m-cresol, 40% p-cresol) in the diet bronchiolar hyperplasia & thyroid Lung/thyroid. LOAEL of 100 mg/kg/d for at levels of 0,1000,3000 or10,000 ppm for 2 follicular years (NTP 2008) US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity toxicity study in rats. Office of Solid Waste, Washington, DC NTP,2008. Toxicology and carcinogenesis studies of cresols (CAS No. 1319- 77-3) in male F344/N rats and female B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. TR-550. Draft technical report. http://www.rivm.nl/en/ http://www.atsdr.cdc.gov/toxprofiles/tp34.html USEPA Integrated Risk Information System (IRIS) n/a n/a n/a http://epa.gov/iris/ Texas Commission on Environmental Quality The value was taken from USEPA Health Effects Assessment Summary Tables (HEAST), July 1997 Not provided Not provided http://www.tceq.state.tx.us/remediation/rrr.html TDI inhal Organisation Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels Description Response Reference Web link TCA was calculated from multiplication of TDI (50 ug/kg/d) by 70kg (mean adult body weight) and divided by 20 m3 (mean adult breathing rate). TCA is provisional because it is derived via route-to-route extrapolation Not provided Not provided http://www.rivm.nl/en/ n/a n/a n/a http://www.atsdr.cdc.gov/toxprofiles/tp34.html (Page 2 of 4) (EIC proforma 4-methylphenol.xls 28/08/2009)
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 4-Methylphenol CAS Number: 106-44-5 Assessor A: Mathew Rouge Assessor B: Gareth Wills Final Review: Panel/SF Date: Mar-09 Date: Apr-09 Date: 28/08/2009 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 1991 Mar-09 Insufficient n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a information exists to derive an RfC Texas Commission on Environmental Quality http://www.tceq.state.tx.us/remediation/r rr.html 2008 Mar-09 RS-ESL 0.01 mg/m3 2.857 Not provided Not provided Not provided Not provided Not provided Not provided Not provided ID oral Recommended IDoral Units N/A Justification No quantitative estimate of carcinogenic risk from oral exposure Organisation Web Link Last Updated Date Web Checked Non threshold effects US Agency for Toxic Substances and http://www.atsdr.cdc.gov/ 2008 Mar-09 No quantitative Disease Registry (ATDSR) Toxicological estimate of Profiles and Minimal Risk levels carcinogenic risk from oral exposure USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 1991 Mar-09 No quantitative estimate of carcinogenic risk from oral exposure Basis Health criteria type Value Units Confidence rating Basis Study type n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a ID inhal Recommended IDinhal N/A Units Justification No quantitative estimate of carcinogenic risk from inhalation exposure Organisation Web Link Last Updated Date Web Checked Non threshold effects US Agency for Toxic Substances and http://www.atsdr.cdc.gov/ 2008 Mar-09 No quantitative Disease Registry (ATDSR) Toxicological estimate of Profiles and Minimal Risk levels carcinogenic risk from inhalation exposure USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 1991 Mar-09 No quantitative estimate of carcinogenic risk from inhalation exposure Basis Health criteria type Value Units Confidence rating Basis Study type n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a (Page 3 of 4) (EIC proforma 4-methylphenol.xls 28/08/2009)
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