Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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4-Methylphenol<br />
TDI oral<br />
Organisation<br />
Description Target organ/Critical Effect Reference Web link<br />
IPCS INCHEM<br />
Based on the results of subchronic studies,<br />
although no further in<strong>for</strong>mation provided<br />
Not provided Not provided http://inchem.org/documents/ehc/ehc/ehc168.htm<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong><br />
and the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
US Agency <strong>for</strong> Toxic Substances and<br />
Disease Registry (ATSDR) Toxicological<br />
Profiles and Minimal <strong>Risk</strong> levels<br />
90 day subchronic toxicity study (US EPA, CNS, Weight loss, neurological events<br />
1986), rats gavaged daily with p-cresol. 90 day<br />
neurotoxicity study (US EPA, 1987), rats<br />
gavaged daily with o-cresol<br />
Groups of female mice were administered m/pcresol<br />
(60% m-cresol, 40% p-cresol) in the diet bronchiolar hyperplasia & thyroid<br />
Lung/thyroid. LOAEL of 100 mg/kg/d <strong>for</strong><br />
at levels of 0,1000,3000 or10,000 ppm <strong>for</strong> 2 follicular<br />
years (NTP 2008)<br />
US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity<br />
toxicity study in rats. Office of Solid Waste, Washington, DC<br />
NTP,2008. Toxicology and carcinogenesis studies of cresols (CAS No. 1319-<br />
77-3) in male F344/N rats and female B6C3F1 mice (feed studies).<br />
Research Triangle Park, NC: National Toxicology Program. TR-550. Draft<br />
technical report.<br />
http://www.rivm.nl/en/<br />
http://www.atsdr.cdc.gov/toxprofiles/tp34.html<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
n/a n/a n/a http://epa.gov/iris/<br />
Texas Commission on Environmental<br />
Quality<br />
The value was taken from USEPA <strong>Health</strong><br />
Effects <strong>Assessment</strong> Summary Tables (HEAST),<br />
July 1997<br />
Not provided Not provided http://www.tceq.state.tx.us/remediation/rrr.html<br />
TDI inhal<br />
Organisation<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong><br />
and the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
US Agency <strong>for</strong> Toxic Substances and<br />
Disease Registry (ATSDR) Toxicological<br />
Profiles and Minimal <strong>Risk</strong> levels<br />
Description Response Reference Web link<br />
TCA was calculated from multiplication of TDI<br />
(50 ug/kg/d) by 70kg (mean adult body weight)<br />
and divided by 20 m3 (mean adult breathing<br />
rate). TCA is provisional because it is derived<br />
via route-to-route extrapolation<br />
Not provided Not provided http://www.rivm.nl/en/<br />
n/a n/a n/a http://www.atsdr.cdc.gov/toxprofiles/tp34.html<br />
(Page 2 of 4) (EIC pro<strong>for</strong>ma 4-methylphenol.xls 28/08/2009)
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