Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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4-Methylphenol CAS Number: 106-44-5 Assessor A: Mathew Rouge Assessor B: Gareth Wills Final Review: Panel/SF
Date: Mar-09 Date: Apr-09 Date: 28/08/2009
Oral
Dermal
Inhalation
Combine Oral
and Inhalation
TDIs
Justification
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Yes Yes Yes
No No No
TDIoral applied to oral, dermal and inhalation
routes. Insufficient data to assess non threshold
effects, so HCV based on threshold effects.
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
No No No
No No No
NR
Insufficient data with sufficient detail on
derivation to derive HCV. Use route-to-route
extrapolation from oral route.
TDI oral
Recommended
TDIoral
Units
100 ug.kg-1.d-1
Justification
Most recent and longer term study data used (ATSDR value for total cresols)
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence Basis Value Units UF UF description Study type
1.d-1
rating
IPCS INCHEM http://inchem.org/ 1995 Mar-09 Acceptable Daily
Intake for cresols
0.17 mg/kg/d 170 No info. NOAEL 50 mg/kg/d 300 10 for interspecies variation; 10 to
account for the lack of chronic
toxicity studies and possible
genotoxic and promoting activity of
cresols and 3 to account for
intraspecies variation based on the
rapid and complete metabolism
Not provided
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
http://www.rivm.nl/en/ 2000 Mar-09 TDI 0.05 mg/kg/d 50 No info. LOAEL 50 mg/kg/d 1000 10 for interspecies, 10 for
Rats gavaged
intraspecies variability and 10 for the daily with p-
lack of a NOAEL
cresol, o-cresol
US Agency for Toxic Substances and
Disease Registry (ATSDR) Toxicological
Profiles and Minimal Risk levels
http://www.atsdr.cdc.gov/ 2008 Mar-09 Minimal Risk Level
(NOAEL) for cresols
0.1 mg/kg/d 100 No info. LOAEL 100 mg/kg/d 1000 10 for extrapolation from animals to chronic oral
humans, 10 for human variability and study in female
10 for use of LOAEL
mice (NTP,2008)
USEPA Integrated Risk Information System
(IRIS)
Texas Commission on Environmental
Quality
http://epa.gov/iris/
http://www.tceq.state.tx.us/remediation/r
rr.html
Mar-09 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a
The Oral RfD for 4-
methylphenol was withdrawn
on 08/01/1991 as a result of
further review. A new RfD
summary is in preparation by
the RfD/RfC Work Group.
2008 Mar-09 RfD 5 ug/kg bw/d 5 No info. NOAEL Not provided Not provided Not provided Not provided Not provided
TDI inhal
Recommended
TDIinhal
N/A
Units
ug.kg-1.d-1
Justification
Insufficient data with sufficient detail to derive HCV
Organisation Last Updated Health criteria type Value Initial Units CLEA units ug.kg- Confidence
1.d-1
rating
Dutch National Institute for Public Health http://www.rivm.nl/en/ 2000 Mar-09 Tolerable
170 ug/m3 48.57 TCA is
and the Environment (RIVM) Maximum
concentration in air
provisional
Permissible Risk (MPR) levels
(TCA)
Basis Value Units UF UF description Study type
Not provided 50 ug/kg/d Not provided Not provided No study
US Agency for Toxic Substances and
Disease Registry (ATSDR) Toxicological
Profiles and Minimal Risk levels
http://www.atsdr.cdc.gov/ 2008 Mar-09 No derivation of
inhalation MRL
because the
inhalation data are
inadequate to
establish
concentrationresponse
relationships
n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a
(Page 1 of 4) (EIC proforma 4-methylphenol.xls 28/08/2009)