Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Contaminant Name: 3-Methylphenol TDI oral Organisation Study type Description Target organ/Critical Effect Reference Web link IPCS INCHEM Not provided Based on the results of subchronic studies, although no further information provided Not provided Not provided http://inchem.org/documents/ehc/ehc/ehc168.htm Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels Rats gavaged daily with p-cresol, o- cresol chronic oral study in female mice (NTP,2008) 90 day subchronic toxicity study (US EPA, 1986), CNS, Weight loss, neurological events rats gavaged daily with p-cresol. 90 day neurotoxicity study (US EPA, 1987), rats gavaged daily with o-cresol Groups of female mice were administered m/pcresol (60% m-cresol, 40% p-cresol) in the diet at bronchiolar hyperplasia & thyroid follicular Lung/thyroid. LOAEL of 100 mg/kg/d for levels of 0,1000,3000 or10,000 ppm for 2 years (NTP 2008) US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity toxicity study in rats. Office of Solid Waste, Washington, DC http://www.rivm.nl/en/ NTP,2008. Toxicology and carcinogenesis studies of cresols (CAS No. 1319-77- http://www.atsdr.cdc.gov/toxprofiles/tp34.html 3) in male F344/N rats and female B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. TR-550. Draft technical report. USEPA Integrated Risk Information System (IRIS) Rats gavaged daily with p-cresol, o- cresol 90 day subchronic toxicity study (US EPA, 1986), CNS, Weight loss, neurological events rats gavaged daily with p-cresol. 90 day neurotoxicity study (US EPA, 1987), rats gavaged daily with o-cresol US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity toxicity study in rats. Office of Solid Waste, Washington, DC http://epa.gov/iris/ TDI inhal Organisation Study type Description Response Reference Web link Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels No study TCA was calculated from multiplication of TDI (50 ug/kg/d) by 70kg (mean adult body weight) and divided by 20 m3 (mean adult breathing rate). TCA is provisional because it is derived via route-to-route extrapolation Not provided Not provided http://www.rivm.nl/en/ US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels n/a n/a n/a n/a http://www.atsdr.cdc.gov/toxprofiles/tp34.html USEPA Integrated Risk Information System (IRIS) n/a n/a n/a The health effects data for 3-methylphenol were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for the derivation of an inhalation RfC. The verification status for this chemical is currently not verifiable http://epa.gov/iris/ (Page 2 of 4) (EIC proforma 3-methylphenol.xls 28/08/2009)
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Contaminant Name: 3-Methylphenol CAS Number: 108-39-4 Assessor A: Mathew Rouge Assessor B: Gareth Wills Final Review: Panel/SF Date: Mar-09 Date: Apr-09 Date: 28/08/2009 Other (Texas Commission on Environmental Quality) http://www.tceq.state.tx.us/remediation/ rrr.html 2008 Mar-09 RS-ESL 0.01 mg/m3 2.857 Not provided Not provided Not provided Not provided Not provided Not provided ID oral Recommended IDoral Units N/A Justification No quantitative estimate of carcinogenic risk from oral exposure Organisation Web Link Last Updated Date Web Checked Non threshold effects US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels http://www.atsdr.cdc.gov/ 2008 Mar-09 No quantitative estimate of carcinogenic risk from oral exposure Basis Health criteria Value Units Confidence rating Basis type n/a n/a n/a n/a n/a n/a n/a n/a n/a USEPA Integrated Risk Information System (IRIS) US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://epa.gov/iris/ 1991 Mar-09 http://rais.ornl.gov/tox/unauthorized.sht ml No quantitative estimate of carcinogenic risk from oral exposure. Carcinogency Classification C; possible human carcinogen 2002 Jul-09 A provisional oral slope factor cannot be derived because human and animal oral cancer data are lacking. n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a ID inhal Recommended IDinhal Units N/A Justification No quantitative estimate of carcinogenic risk from inhalation exposure Organisation Web Link Last Updated Date Web Checked Non threshold effects US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) http://www.atsdr.cdc.gov/ 2008 Mar-09 No quantitative estimate of carcinogenic risk from inhalation exposure http://epa.gov/iris/ 1991 Mar-09 No quantitative estimate of carcinogenic risk from inhalation exposure. Carcinogenicity Classification C; possible human carcinogen Basis Health criteria Value Units Confidence rating Basis type n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a (Page 3 of 4) (EIC proforma 3-methylphenol.xls 28/08/2009)
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