Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948<br />
Contaminant Name: 3-Methylphenol<br />
TDI oral<br />
Organisation<br />
Study type Description Target organ/Critical Effect Reference Web link<br />
IPCS INCHEM<br />
Not provided<br />
Based on the results of subchronic studies,<br />
although no further in<strong>for</strong>mation provided<br />
Not provided Not provided http://inchem.org/documents/ehc/ehc/ehc168.htm<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong><br />
and the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATSDR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
Rats gavaged daily<br />
with p-cresol, o-<br />
cresol<br />
chronic oral study<br />
in female mice<br />
(NTP,2008)<br />
90 day subchronic toxicity study (US EPA, 1986), CNS, Weight loss, neurological events<br />
rats gavaged daily with p-cresol. 90 day<br />
neurotoxicity study (US EPA, 1987), rats gavaged<br />
daily with o-cresol<br />
Groups of female mice were administered m/pcresol<br />
(60% m-cresol, 40% p-cresol) in the diet at bronchiolar hyperplasia & thyroid follicular<br />
Lung/thyroid. LOAEL of 100 mg/kg/d <strong>for</strong><br />
levels of 0,1000,3000 or10,000 ppm <strong>for</strong> 2 years<br />
(NTP 2008)<br />
US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity<br />
toxicity study in rats. Office of Solid Waste, Washington, DC<br />
http://www.rivm.nl/en/<br />
NTP,2008. Toxicology and carcinogenesis studies of cresols (CAS No. 1319-77- http://www.atsdr.cdc.gov/toxprofiles/tp34.html<br />
3) in male F344/N rats and female B6C3F1 mice (feed studies). Research<br />
Triangle Park, NC: National Toxicology Program. TR-550. Draft technical<br />
report.<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
Rats gavaged daily<br />
with p-cresol, o-<br />
cresol<br />
90 day subchronic toxicity study (US EPA, 1986), CNS, Weight loss, neurological events<br />
rats gavaged daily with p-cresol. 90 day<br />
neurotoxicity study (US EPA, 1987), rats gavaged<br />
daily with o-cresol<br />
US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity<br />
toxicity study in rats. Office of Solid Waste, Washington, DC<br />
http://epa.gov/iris/<br />
TDI inhal<br />
Organisation<br />
Study type Description Response Reference Web link<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong><br />
and the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
No study<br />
TCA was calculated from multiplication of TDI<br />
(50 ug/kg/d) by 70kg (mean adult body weight)<br />
and divided by 20 m3 (mean adult breathing<br />
rate). TCA is provisional because it is derived via<br />
route-to-route extrapolation<br />
Not provided Not provided http://www.rivm.nl/en/<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATDSR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
n/a n/a n/a n/a http://www.atsdr.cdc.gov/toxprofiles/tp34.html<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
n/a n/a n/a The health effects data <strong>for</strong> 3-methylphenol were reviewed by the U.S. EPA<br />
RfD/RfC Work Group and determined to be inadequate <strong>for</strong> the derivation of<br />
an inhalation RfC. The verification status <strong>for</strong> this chemical is currently not<br />
verifiable<br />
http://epa.gov/iris/<br />
(Page 2 of 4) (EIC pro<strong>for</strong>ma 3-methylphenol.xls 28/08/2009)
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