Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Contaminant Name: 3-Methylphenol CAS Number: 108-39-4 Assessor A: Mathew Rouge Assessor B: Gareth Wills Final Review: Panel/SF
Date: Mar-09 Date: Apr-09 Date: 28/08/2009
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Oral Dermal Inhalation Combine Oral
and Inhalation
TDIs
Yes Yes Yes
No No No
Justification
TDIoral applied to oral, dermal and inhalation
routes. Insufficient data to assess non threshold
effects, so HCV based on threshold effects.
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
No No No
No No No
NR
Insufficient data with sufficient detail on
derivation to derive HCV. Use route-to-route
extrapolation from oral route. Insufficient data to
assess non threshold effects, so HCV based on
threshold effects.
TDI oral
Recommended TDIoral Units
100 μg.kg-1.d-1
Justification
Most recent and longer term study data used (ATSDR value for total cresols)
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
IPCS INCHEM http://inchem.org/ 1995 Mar-09 Acceptable Daily
Intake for cresols
Confidence
rating
Basis Value Units UF UF description
0.17 mg/kg/d 170 No info. NOAEL 50 mg/kg/d 300 10 for interspecies variation; 10 to
account for the lack of chronic toxicity
studies and possible genotoxic and
promoting activity of cresols and 3 to
account for intraspecies variation
based on the rapid and complete
metabolism
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
http://www.rivm.nl/en/ 2000 Mar-09 TDI 0.05 mg/kg/d 50 No info. LOAEL 50 mg/kg/d 1000 10 for interspecies, 10 for intraspecies
variability and 10 for the lack of a
NOAEL
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
http://www.atsdr.cdc.gov/ 2008 Mar-09 Minimal Risk Level
(NOAEL) for cresols.
Also provides IRIS
RfD below for o-
cresol
0.1 mg/kg/d 100 No info. LOAEL 100 mg/kg/d 1000 10 for extrapolation from animals to
humans, 10 for human variability and
10 for use of LOAEL
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ 1990 Mar-09 RfD 0.05 mg/kg/d 50 Study - High,
Database -
Med, RfD -
Med
NOAEL 50 mg/kg/d 1000 10 for interspecies, 10 for intraspecies
variability and 10 for uncertainty in
extrapolation of subchronic data to
levels of chronic effects
TDI inhal
Recommended
TDIinhal
N/A
Units
μg.kg-1.d-1
Justification
Insufficient data with sufficient detail to derive HCV
Organisation Last Updated Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
http://www.rivm.nl/en/ 2000 Mar-09 Tolerable
concentration in air
(TCA)
Confidence
rating
170 ug/m3 50 TCA is
provisional
Basis Value Units UF UF description
Not provided Not provided Not provided Not provided Not provided
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
http://www.atsdr.cdc.gov/ 2008 Mar-09 No derivation of
inhalation MRL
because the
inhalation data are
inadequate to
establish
concentrationresponse
relationships
n/a n/a n/a n/a n/a n/a n/a n/a n/a
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ 1991 Mar-09 Insufficient
information exists to
derive an RfC
n/a n/a n/a n/a n/a n/a n/a n/a n/a
(Page 1 of 4) (EIC proforma 3-methylphenol.xls 28/08/2009)