Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

More documents

Recommendations

Info

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2-Methylphenol TDI oral Organisation Description Target organ/Critical Effect Reference Web link IPCS INCHEM Based on the results of subchronic studies, although no further information provided Not provided Not provided http://inchem.org/documents/ehc/ehc/ehc168.htm Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels 90 day subchronic toxicity study (US EPA, CNS, Weight loss, neurological events 1986), rats gavaged daily with p-cresol. 90 day neurotoxicity study (US EPA, 1987), rats gavaged daily with o-cresol Groups of female mice were administered m/pcresol (60% m-cresol, 40% p-cresol) in the diet bronchiolar hyperplasia & thyroid Lung/thyroid. LOAEL of 100 mg/kg/d for at levels of 0,1000,3000 or10,000 ppm for 2 follicular years (NTP 2008) US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity toxicity study in rats. Office of Solid Waste, Washington, DC NTP,2008. Toxicology and carcinogenesis studies of cresols (CAS No. 1319- 77-3) in male F344/N rats and female B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. TR-550. Draft technical report. http://www.rivm.nl/en/ http://www.atsdr.cdc.gov/toxprofiles/tp34.html USEPA Integrated Risk Information System (IRIS) 90 day subchronic toxicity study (US EPA, CNS, Weight loss, neurological events 1986), rats gavaged daily with p-cresol. 90 day neurotoxicity study (US EPA, 1987), rats gavaged daily with o-cresol US EPA. 1986/1987. o,m,p-cresol.90-Day oral subchronic/neurotoxicity toxicity study in rats. Office of Solid Waste, Washington, DC http://epa.gov/iris/ TDI inhal Organisation Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels Description Response Reference Web link TCA was calculated from multiplication of TDI (50 ug/kg/d) by 70kg (mean adult body weight) and divided by 20 m3 (mean adult breathing rate). TCA is provisional because it is derived via route-to-route extrapolation Not provided Not provided http://www.rivm.nl/en/ n/a n/a n/a http://www.atsdr.cdc.gov/toxprofiles/tp34.html USEPA Integrated Risk Information System (IRIS) Texas Commission on Environmental Quality n/a n/a The health effects data for 2-methylphenol were reviewed by the U.S. EPA http://epa.gov/iris/ RfD/RfC Work Group and determined to be inadequate for the derivation of an inhalation RfC. The verification status for this chemical is currently not verifiable Not Provided Not Provided Not Provided http://www.tceq.state.tx.us/remediation/rrr.html (Page 2 of 4) (EIC proforma 2-methylphenol.xls 28/08/2009)
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2-Methylphenol CAS Number: 95-48-7 Assessor A: Mathew Rouge Assessor B: Gareth Wills Final Review: Date: March 09 Date: April 09 Date: Panel/SF 28/08/2009 ID oral Recommended IDoral Units N/A Justification No quantitative estimate of carcinogenic risk from oral exposure Organisation Web Link Last Updated Date Web Checked Non threshold effects US Agency for Toxic Substances and http://www.atsdr.cdc.gov/ 2008 Mar-09 No quantitative Disease Registry (ATDSR) Toxicological estimate of Profiles and Minimal Risk levels carcinogenic risk from oral exposure USEPA Integrated Risk Information System (IRIS) US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://epa.gov/iris/ 1991 Mar-09 No quantitative estimate of carcinogenic risk from oral exposure. Carcinogenic Classification C; possible human carcinogen http://rais.ornl.gov/tox/unauthorized.shtml 31/01/2002 Jul-09 A provisional oral slope factor cannot be derived because human and animal oral cancer data are lacking. Basis Health criteria Value Units Confidence rating Basis Study type type n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a ID inhal Recommended IDinhal N/A Units Justification No quantitative estimate of carcinogenic risk from inhalation exposure Organisation Web Link Last Updated Date Web Checked Non threshold effects US Agency for Toxic Substances and http://www.atsdr.cdc.gov/ 2008 Mar-09 No quantitative Disease Registry (ATDSR) Toxicological estimate of Profiles and Minimal Risk levels carcinogenic risk from inhalation exposure USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 1991 Mar-09 No quantitative estimate of carcinogenic risk from inhalation exposure. Carcinogen Classification - C; possible human carcinogen Basis Health criteria type Value Units Confidence rating Basis Study type n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a (Page 3 of 4) (EIC proforma 2-methylphenol.xls 28/08/2009)
Page 1 and 2:
www.esdat.net Esdat Environmental D
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80: www.esdat.net Esdat Environmental D
Page 103 and 104: 1,3,5-Trimethylbenzene CAS 108-67-8
Page 129: www.esdat.net Esdat Environmental D
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321:
show all

Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?