Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Substance: 2-Chloronaphthalene CAS Number: 91-58-7 Assessor A: K Privett, Hydrock Assessor B: Y Macklin, Amec Final review: Panel/SF Chemical Formula: C10H7Cl Phase at Ambient Solid Tempertaure Date: 16/03/2009 Date: 08/05/2009 Date: 26/08/2009 http://srdata.nist.gov/solubility/ http://webbook.nist.gov/chemistry/ A B C D E F G Property Units Calculated Value Adopted Value Ref. Temp (C) Rationale References HOWARD, 1990 LIDE, 2008 MACKAY et al, 2006 MERCK, 2006 MONTGOMERY, 2007 MONTGOMERY, 1997 NIST, 2005 Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Source Units SR7 Units Source Units SR7 Units Source Units SR7 Units Source Units SR7 Units Source Units SR7 Units (C) (C) (C) (C) (C) (C) Required Parameters Relative Molecular Mass g mol -1 n/a 162.62 n/a Consensus http://cs3-hq.oecd.org/scripts/hpv/ H OECD, 2000 Ref. Temp Source Units SR7 Units (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) Average #VALUE! n/a 162.616 n/a 162.616 n/a 162.62 n/a 162.62 n/a #VALUE! n/a 162.6153 n/a #VALUE! n/a no data #VALUE! n/a 162.616 162.616 n/a 162.616 162.616 n/a 162.62 162.62 n/a 162.62 162.62 n/a no data #VALUE! n/a 162.6153 162.6153 n/a no data #VALUE! n/a atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) KPa m3 mol-1 Pa m3 mol-1 Ref. Temp (C) Pa m3 mol-1 Pa m3 mol-1 Ref. Temp (C) n/a n/a n/a atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) mol kg-1 bar-1 Pa m3 mol-1 Ref. Temp (C) atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) Henry's Law Constant (HLC) Pa m3 mol-1 n/a 33.5 25 No consistent range - median value from most recent review chosen (Lide 2008) Geomean #VALUE! 3.35E+01 25 3.27E+01 25 3.35E+01 25 #VALUE! 3.76E+01 25 #VALUE! no data #VALUE! 0.0335 3.35E+01 31.9 31.9 3.31E-04 33.538575 no data #VALUE! 3.1 3.24E+01 no data #VALUE! 33.5 33.5 1.6 6.27E+01 3.2 3.13E+01 3.2 3.13E+01 25 25 n/a n/a n/a 25 25 Solubility (S) 10 oC where possible. (Use unit converter if source provides different units) mg/L n/a 11.7 25 No consistent range - median value from most recent review chosen (Lide 2008) mg/L mg/L Ref. Temp (C) g/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) Geomean #VALUE! 1.17E+01 25 6.57E+00 25 #VALUE! #VALUE! 22 #VALUE! #VALUE! #VALUE! no data #VALUE! 1.17E-02 11.7 11.7 1.17E+01 no data #VALUE! no data #VALUE! no data #VALUE! no data #VALUE! no data #VALUE! 0.924 9.24E-01 8.93 8.93E+00 16.3 1.63E+01 25 7.8 7.80E+00 25 22 o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) K K Ref. Temp (C) o C K Ref. Temp (C) Chemical Boiling Point (ambient pressure) K n/a 529 n/a Consensus Average #VALUE! n/a 5.29E+02 n/a 5.29E+02 n/a 5.29E+02 n/a 5.29E+02 n/a #VALUE! n/a Insert Values n/a #VALUE! n/a no data #VALUE! n/a 256 529.15 n/a 256 529.15 n/a 256 529.15 n/a 256 529.15 n/a no data #VALUE! n/a no data no data n/a no data #VALUE! n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) K K Ref. Temp (C) o C K Ref. Temp (C) Chemical Melting Point (ambient pressure) K n/a 331 n/a Consensus Average #VALUE! n/a 3.31E+02 n/a 3.31E+02 n/a 3.33E+02 n/a 3.31E+02 n/a #VALUE! n/a Insert Values n/a #VALUE! n/a no data #VALUE! n/a 58 331.15 n/a 58 331.15 n/a 59.5 332.65 n/a 58 331.15 n/a no data #VALUE! n/a no data no data n/a no data #VALUE! n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Log Octanol - Water Coefficient Dimensionless n/a 3.98 n/a Value from most recent study as only 2 values Average Insert Values n/a 3.98E+00 n/a 4.21E+00 n/a Insert Values n/a 4.01E+00 n/a Insert Values n/a Insert Values n/a Insert Values n/a no data no data n/a 3.98 3.98 n/a 4.8 4.80 n/a no data no data n/a 3.91 3.91 n/a no data no data n/a no data no data n/a no data no data n/a n/a n/a 4.19 4.19 n/a n/a 3.98 3.98 n/a n/a n/a n/a n/a n/a 4.08 4.08 n/a n/a 4.14 4.14 n/a n/a n/a n/a n/a n/a 3.98 3.98 n/a n/a n/a n/a n/a n/a n/a n/a 4.07 4.07 n/a n/a n/a n/a n/a n/a n/a n/a 4.8024 4.80 n/a n/a n/a n/a n/a n/a n/a n/a 4.14 4.14 n/a n/a n/a n/a n/a n/a n/a n/a 3.9 3.90 n/a n/a n/a n/a n/a n/a n/a n/a 3.91 3.91 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Molar Volume (Le Bas method) cm3 mol-1 n/a 169 n/a Single value cm3 mol-1 cm3 mol-1 Ref. Temp (C) n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Average 1.69E+02 n/a 168.5 168.50 n/a Enthalpy of Vaporisation at normal boiling point (EVNBP) J Mol-1 47718.68387 4.77E+04 Normal Chemical Boiling Point Calculated value as no data KJ mol-1 J Mol-1 KJ mol-1 J Mol-1 KJ mol-1 J Mol-1 Ref. Temp (C) Average #VALUE! #VALUE! #VALUE! n/a n/a n/a no data #VALUE! Normal no data #VALUE! Normal n/a n/a n/a n/a n/a n/a n/a n/a n/a no data #VALUE! Normal Boiling Boiling Boiling Point Point Point n/a n/a n/a Chemical Critical Point temperature (ambient pressure) Critical Pressure K K Ref. Temp (C) o C K Ref. Temp (C) K K Ref. Temp (C) o C K Ref. Temp (C) K 780.6057495 780.6 n/a Calculated value as no Average Insert Values n/a #VALUE! n/a Insert Values n/a #VALUE! n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a data no data no data n/a no data #VALUE! n/a no data no data n/a no data #VALUE! n/a n/a n/a n/a n/a n/a n/a n/a n/a Bar Atmosph Ref. Temp (C) Bar Atmosph Ref. Temp (C) Average #VALUE! #VALUE! atm 33.59917355 33.60 no data #VALUE! no data #VALUE! Calculated value as no n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a data n/a n/a n/a Calcuated parameters for input to CLEA model (UPDATED FROM THE SPREADSHEET TOOL) Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Air-water partition coefficient at ambient soil temperature cm 3 .cm -3 3.78E-03 10 Estimated from parameters above using Clapyron relationship or direct calculation Vapour pressure at ambient soil temperature Pa 0.501 10 Estimated from parameters above using Grain- Watson method Diffusion coefficient in air m 2 .s -1 5.95E-06 10 Estimated from parameters above using Wilkie-Lee method Diffusion coefficient in water m 2 .s -1 4.77E-10 10 Estimated from parameters above using Hayduk and Laudie method Organic carbonwater partition coefficient Log cm 3 .g -1 3.32 n/a Estimated from parameters above using equation in Table 2.12 of SR7 Page 1 of 1 EIC proforma 2-chloronaphthalene.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2-Methylnaphthalene CAS Number: 91-57-6 Assessor A: Andreas Neymeyer, Buro Happold Assessor B: Mike Rogers, OPUS JOYNES PIKE Ltd Final review: Panel/SF Date 16/04/2009 Date 16/04/2009 Date 28/08/2009 Apply TDIoral to exposure routes Apply IDoral to exposure routes Apply TDIinh to exposure routes Apply IDinh to exposure routes Oral Inhalation Dermal Yes Yes No No No No No No No No No No Combine Oral and Inhalation TDIs NR Justification Chronic dietary studies with 1- or 2-methylnaphthalene provided limited evidence for carcinogenicity. No inhalation route health criteria value. Likely to be similar to naphthalene, i.e. inhalation orders of magnitude more toxic than oral TDI oral Recommended TDIoral Units 4 ug.kg-1.d-1 Justification Lowest literature oral Reference Dose (RfD) [USEPA Integrated Risk Information System (IRIS)] Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- 1.d-1 US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels http://www.atsdr.cdc.gov/ 09/03/2009 27/03/2009 MRL (substancespecific Minimal Risk Level) 0.04 mg/kg/day 40 LOAEL Confidence rating Basis Value Units UF UF description Study type BMDL05 50.3 mg/kg body weight per day 4 100 Based on the lower 95% confidence animal (mice) limit on a benchmark dose associated with 5% extra risk (BMDL05=4 mg/kg/day) for pulmonary alveolar proteinosis in male mice exposed to 2-methylnaphthalene in the diet for 81 weeks and an uncertainty factor of 100 (10 for extrapolation from animals to humans and 10 for human variability) USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 09/03/2009 27/03/2009 RfD 0.004 mg/kg/day 4 BMDL05 3.5 mg/kg body weight per day 1000 A total uncertainty factor of 1000 was animal (mice) applied to the BMDL05 of 3.5 mg/kgday: 10 for extrapolation for interspecies differences (UFA: animal to human); 10 for consideration of intraspecies variation (UFH: human variability); and 10 for deficiencies in the database (UFD). US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://rais.ornl.gov/tox/unauthorized.shtml Sep-07 15/07/2009 p-RFD 0.004 mg/kg/day 4 BMDL05 3.5 mg/kg body weight per day 1000 A total UF of 1000 was applied to this animal (mice) effect level: 10 for interspecies differences (UFA: animal to human); 10 for intraspecies variation (UFH: human variability); and 10 for deficiencies in the database (UFD). TDI inhal Recommended TDIinhal Units n/a Justification Insufficient data for the assessment of chronic risk to humans Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description Study type 1.d-1 USEPA Integrated Risk Information System http://epa.gov/iris/ Insufficient data for the assessment of chronic risk to humans with respect to the inhalation pathway (IRIS) US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://rais.ornl.gov/tox/unauthorized.shtml ID oral Recommended IDoral Units n/a Justification Chronic dietary studies with 1- or 2-methylnaphthalene provided limited evidence for carcinogenicity. Organisation Web Link Last Updated Date Web Checked Non threshold effects US EPA Provisional Peer Reviewed Toxicity http://rais.ornl.gov/tox/unauthorized.shtml Values (PPRTV) Basis Health criteria type Value Units Confidence rating Basis Study type Quantitative estimates of cancer risk for 2-MN could not be derived because no data demonstrating carcinogenicity associated with 2-MN exposure were identified. ID inhal Recommended IDinhal Units n/a Justification Chronic dietary studies with 1- or 2-methylnaphthalene provided limited evidence for carcinogenicity. Organisation Web Link Last Updated Date Web Checked Non threshold effects US EPA Provisional Peer Reviewed Toxicity http://rais.ornl.gov/tox/unauthorized.shtml Values (PPRTV) Basis Health criteria type Value Units Confidence rating Basis Study type Page 1 of 2 EIC proforma 2-methylnaphthalene.xls 28/08/2009
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