Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2-chloronaphthalene TDI oral Organisation Description Target organ/Critical Effect Reference Web link IPCS concise International Chemical Assessment Documents (CICADs) CICAD 34 (2001) Chlorinated Naphthalenes http://www.inchem.org/documents/cicads/cicads/cicad34.htm Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels. 13 week study in mice (see detailed description below). Liver US EPA study (see below) http://www.rivm.nl/bibliotheek/rapporten/711701023.pdf http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf USEPA Integrated Risk Information System (IRIS) CD-1 mice (20/sex/group) were administered Dyspnea, abnormal appearance, liver oral gavage dosages of 0, 100, 250, or 600 enlargement mg/kg/day beta-chloronaphthalene in corn oil for 13 weeks. Parameters examined included mortality, body and organ weight changes, food consumption, clinical signs, ophthalmologic changes, haematology, clinical chemistry, and gross histopathology. The LOAEL was identified as 600 mg/kg/day and the NOAEL was 250 mg/kg/day. U.S. EPA. 1989. Subchronic study in mice with beta-Chloronaphthalene. HLA Study No. 2399-124. Prepared by Hazleton Laboratories America, Inc. for U.S. EPA, Office of Solid Waste, Washington, DC. http://www.epa.gov/ncea/iris/subst/0463.htm Toxicology Data Network (Toxnet) As per USEPA study USEPA study above USEPA study above USEPA study above TDI inhal Organisation Description Response Reference Web link Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels Rats exposed for a period of 134 days, 16 hours per day. Liver TSD (1993) Environmental Hazard Assessment: halogenated naphthalenes. Toxic Substances Division, Dir. Air, Climate and Toxic Substances. Building Res. Establishment, Garston, Watford UK. http://www.rivm.nl/bibliotheek/rapporten/711701023.pdf http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf ID oral Organisation Description Response Reference Web link ID inhal Organisation Description Response Reference Web link Page 2 of 2 EIC proforma 2-chloronaphthalene.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2-chloronaphthalene CAS 91-58-7 Assessor A: Y Macklin, AMEC Assessor B: K Privett, Hydrock Final review: Panel/SF Date 25/03/2009 Date 08/05/2009 Date 26/08/2009 MDI Recommended MDIoral Units 0.0001 ug day-1 Justification: value for Netherlands in drinking water is used as considered most relevant to UK. Contribution from dietary sources is negligible. Organisation Date Media Value Units Description Reference Web link IPCS Concise International Chemical Assessment Documents (CICADs) 08/04/2009 Drinking water 0.00088 ng/l Study on levels of mono and dichloronaphthalene in drinking water in Japan. After chlorination, levels of 0.03–0.44 ng/litre for chloronaphthalene and levels of not detected to 0.15 ng/litre for dichloronaphthalene. Multiply by 2l per day for adult consumption. Convert from ng/l to μg/l divide by 1,000. Shiraishi H, Pilkington NH, Otsuki A, Fuwa K (1985) Occurrence of chlorinated polynuclear aromatic compounds in tap water. Environmental science and technology, 19:585–590. http://inchem.org/pages/cicads.html Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) Levels 08/04/2009 Drinking water and food 0.0001 μg/day Chloronaphthalene can be found in drinking water after chlorination processing, leading to a daily intake in the order of 0.1 ng. The exposure of the population from 1- and 2-chloronaphthalene from food is negligible. Convert from ng/l to μg/l divide by 1,000. TSD (1993) Environmental Hazard Assessment: halogenated naphthalenes. Toxic Substances Division, Dir. Air, Climate and Toxic Substances. Building Res. Establishment, Garston, Watford UK. (http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf) www.rivm.nl/en/ MDI Recommended MDIinh Units 0.02 ug day-1 Justification: Netherlands value used as study is likely to be more relevant to the UK. Organisation Date Media Value Units Description Reference Web link IPCS Concise International Chemical Assessment Documents (CICADs) 08/04/2009 Ambient air 0.003 μg day-1 Chlorinated naphthalene concentrations of up to 150 pg/m 3 at "semi rural" sites and 1–40 pg/m 3 at remote sites. Conversion from original data: multiply by 20m 3 to allow for adult inhalation according EA toxicological guidance. Convert from pg/day to μg/day divide by 1,000,000. http://www.inchem.org/documents/cicads/cicads/cicad34.htm http://inchem.org/pages/cicads.html Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) Levels 08/04/2009 Ambient air 0.02 μg day-1 According to TSD (1993) the lower chlorinated naphthalenes can be found in ambient air in the neighbourhood if different sources, from these data a concentration in the order of 1 ng/m 3 can be estimated in residential areas. Conversion from original data: multiply by 20m 3 . Convert from ng/day to μg/day divide by 1,000. TSD (1993) Environmental Hazard Assessment: halogenated naphthalenes. Toxic Substances Division, Dir. Air, Climate and Toxic Substances. Building Res. Establishment, Garston, Watford UK. (http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf) www.rivm.nl/en/ Page 1 of 1 EIC proforma 2-chloronaphthalene.xls 26/08/2009
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