Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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2-chloronaphthalene CAS Number: 91-58-7 Assessor A: Y Macklin, AMEC Assessor B: K Privett, Final review: Panel/SF
Hydrock
Date 25/03/2009 Date 08/05/2009 Date 26/08/2009
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
Oral Dermal Inhalation Combine Oral
and Inhalation
TDIs
Yes Yes No
No No No
No No Yes
No No No
Yes
Justification
Not evaluated for human carcinogenicity (IRIS).
Not evaluated for human carcinogenicity (IRIS).
TDI oral Recommended TDIoral Units
80 ug.kg-1.d-1
Justification
Consensus between IRIS and RIVM.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description Study type
1.d-1
IPCS concise International Chemical
Assessment Documents (CICADs)
http://inchem.org/pages/cicads.html unknown 08/04/2009 Concludes that there is
not sufficient
information to derive
NOAEL or LOAEL
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels.
http://www.rivm.nl/en/ unknown 08/04/2009 TDI
(chloronaphthalenes-
SUM)
80 μg/kg bw/day 80 Low NOAEL 250 mg/kg bw/day 3000 An uncertainty factor of 3000 reflects
10 each for inter- and intraspecies
conversion, 10 for the use of a
subchronic study for chronic RfD
derivation, and 3 to account for the
lack of reproductive/developmental
and chronic toxicity data.
Mouse
Subchronic Oral
Gavage Study.
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ 23/01/2008 08/04/2009 RfD for betachloronaphthalene
8.00E-02 mg/kg bw/day 80 Low/medium LOAEL
NOAEL
600
250
mg/kg/day
mg/kg/day
3000 An uncertainty factor of 3000 reflects
10 each for inter- and intraspecies
conversion, 10 for the use of a
subchronic study for chronic RfD
derivation, and 3 to account for the
lack of reproductive/developmental
and chronic toxicity data.
Mouse
Subchronic Oral
Gavage Study.
Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ unknown 08/04/2009 RfD 8.00E-02 mg/kg bw/day 80 LOAEL
NOAEL
600
250
mg/kg/day
mg/kg/day
3000 An uncertainty factor of 3000 reflects
10 each for inter- and intraspecies
conversion, 10 for the use of a
subchronic study for chronic RfD
derivation, and 3 to account for the
lack of reproductive/developmental
and chronic toxicity data.
TDI inhal
Recommended
TDIinhal
Units
0.286 ug.kg-1.d-1
Justification
In the absence of any other data the provisional Dutch RIVM value has been adopted.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description Study type
1.d-1
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
http://www.rivm.nl/en/ unknown 08/04/2009 provisional TCA 1 μg/m3 0.286 Low NOAEC 1.3 mg/m3 900 3 x for extrapolation of LOAEC to
NOAEC. An additional UK of 100 for
inter- and intraspecies variation. And
a further factor of 3 is used to correct
for the restricted database. With a
correction factor of 0.7 for
continuous exposure.
ID oral Recommended IDoral Units
n/a
Justification
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
Organisation Web Link Last Updated Date Web Checked Non threshold
effects
Basis
Health criteria
type
Value Units Confidence rating
Basis
Study type
ID inhal Recommended IDinhal Units
n/a
Justification
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
Organisation Web Link Last Updated Date Web Checked Non threshold
effects
Basis
Health criteria
type
Value Units Confidence rating
Basis
Study type
Page 1 of 2 EIC proforma 2-chloronaphthalene.xls 26/08/2009