Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2,6-Dinitrotoluene TDI oral Organisation Study type Description Target organ/Critical Effect Reference Web link International Agency for Research on Cancer (IARC) US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels 2,4- and 2,6-Dinitrotoluenes are possibly carcinogenic to humans (Group 2B). Toxicological Profile for 2,4- and 2,6-Dinitrotoluene December 1998 and ATSDR Minimal Risk Levels (MRLs) December 2008 http://www.atsdr.cdc.gov/toxprofiles/tp109.html http://www.atsdr.cdc.gov/mrls/ USEPA Health Advisors Dog Feeding 13- week study The dogs (4/sex/dose) were given 2,6-DNT in capsules at doses of 0, 4, 20, or 100 mg/kg/day for 13 weeks. There were no adverse effects observed in the low-dose animals. 2,6-DNT did, however, produce toxicity at higher dose levels The animals had BW loss due to decreased food consumption. Adverse effects in this study were neurological and hematological, and there were altered clinical chemistry parameters. There also were bile duct hyperplasia and histopathological effects to the liver and kidneys of both sexes and to the testes in males. Drinking Water Health Advisories 2006 Edition and Drinking Water Health Advisory for 2,4-Dinitrotoluene and 2,6-Dinitrotoluene http://www.epa.gov/waterscience/criteria/drinking/dwstandards www.epa.gov/safewatr/ccl/pdf/DNTs.pdf US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) Dog Feeding 13-week study The dogs (4/sex/dose) were given 2,6-DNT in capsules at doses of 0, 4, 20, or 100 mg/kg/day for 13 weeks. There were no adverse effects observed in the low-dose animals. 2,6-DNT did, however, produce toxicity at higher dose levels The animals had BW loss due to decreased food consumption. Adverse effects in this study were neurological and hematological, and there were altered clinical chemistry parameters. There also were bile duct hyperplasia and histopathological effects to the liver and kidneys of both sexes and to the testes in males. Lee, C-C., H.V. Ellis, J.J. Kowalski et al. 1976. Mammalian toxicity of munition compounds Phase II: Effects of multiple doses. Part III: 2,6- Dinitrotoluene. Study conducted by the Midwest Research Institute for the U.S. Medical Bioengineering Research and Development Laboratory. Fort Detrick, Frederick, MD. AD A 062 015. TDI inhal Organisation Study type Description Response Reference Web link ID oral Organisation Study type Description Response Reference Web link ID inhal Organisation Study type Description Response Reference Web link Page 2 of 2 EIC proforma 2,6-dinitrotoluene.xls 28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2,6-Dinitrotoluene CAS 606-20-2 Assessor A: D, Brooks, Sirius Assessor B: J Lymer, Wardell Armstrong Final review: Panel/SF Date 13/03/2009 Date 14/04/2009 Date 28/08/2009 MDI Recommended MDIoral Units 0 ug day-1 Justification: No data, background exposure assumed negligible in comparison to HCV. HCV is equivalent to drinking water concentration of 35μg/L based on a 70kg adult consuming 2L/day. Organisation Date Media Value Units Description Reference Web link Justification: No data, likely to be negligible MDI Recommended MDIinh Units 0 ug day-1 Organisation Date Media Value Units Description Reference Web link Page 1 of 1 EIC proforma 2,6-dinitrotoluene.xls 28/08/2009
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