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2,6-Dinitrotoluene
TDI oral
Organisation
Study type Description Target organ/Critical Effect Reference Web link
International Agency for Research on
Cancer (IARC)
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
2,4- and 2,6-Dinitrotoluenes are possibly
carcinogenic to humans (Group 2B).
Toxicological Profile for 2,4- and 2,6-Dinitrotoluene December 1998 and
ATSDR Minimal Risk Levels (MRLs) December 2008
http://www.atsdr.cdc.gov/toxprofiles/tp109.html
http://www.atsdr.cdc.gov/mrls/
USEPA Health Advisors
Dog Feeding 13-
week study
The dogs (4/sex/dose) were given 2,6-DNT in
capsules at doses of 0, 4, 20, or 100 mg/kg/day
for 13 weeks. There were no adverse effects
observed in the low-dose animals. 2,6-DNT did,
however, produce toxicity at higher dose levels
The animals had BW loss due to decreased
food consumption. Adverse effects in this
study were neurological and
hematological, and there were altered
clinical chemistry parameters. There also
were bile duct hyperplasia and
histopathological effects to the liver and
kidneys of both sexes and to the testes in
males.
Drinking Water Health Advisories
2006 Edition and Drinking Water Health Advisory
for 2,4-Dinitrotoluene and 2,6-Dinitrotoluene
http://www.epa.gov/waterscience/criteria/drinking/dwstandards
www.epa.gov/safewatr/ccl/pdf/DNTs.pdf
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
Dog Feeding
13-week study
The dogs (4/sex/dose) were given 2,6-DNT in
capsules at doses of 0, 4, 20, or 100 mg/kg/day
for 13 weeks. There were no adverse effects
observed in the low-dose animals. 2,6-DNT did,
however, produce toxicity at higher dose levels
The animals had BW loss due to decreased
food consumption. Adverse effects in this
study were neurological and
hematological, and there were altered
clinical chemistry parameters. There also
were bile duct hyperplasia and
histopathological effects to the liver and
kidneys of both sexes and to the testes in
males.
Lee, C-C., H.V. Ellis, J.J. Kowalski et al. 1976. Mammalian toxicity of
munition compounds Phase II: Effects of multiple doses. Part III: 2,6-
Dinitrotoluene. Study conducted by the Midwest Research Institute for
the U.S. Medical Bioengineering Research and Development
Laboratory. Fort Detrick, Frederick, MD. AD A 062 015.
TDI inhal
Organisation
Study type Description Response Reference Web link
ID oral
Organisation
Study type Description Response Reference Web link
ID inhal
Organisation
Study type Description Response Reference Web link
Page 2 of 2 EIC proforma 2,6-dinitrotoluene.xls 28/08/2009