Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

More documents

Recommendations

Info

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2,4-Dinitrotoluene TDI oral Organisation Description Target organ/Critical Effect Reference Web link European Chemicals Bureau (ECB) International Agency for Research on Cancer (IARC) Organisation for Economic Co-operation and Development (OECD) Screening Information Data Set (SIDS) for High Production Volume Chemicals N/A 2,4- and 2,6-Dinitrotoluenes are possibly carcinogenic to humans (Group 2B). the critical effects for risk characterisation derived from the 24-month rat study were presence of hyperplastic foci in the liver and atrophy of seminiferous tubules. No teratogenic effects were recorded and impairment of fertility were observed at doses which also cause other effects. European Union Risk Assessment Report 2,4-dinitrotoluene 2,4-Dinitrotoluene ecb.jrc.ec.europa.eu/documents/Existing- Chemicals/RISK_ASSESSMENT/REPORT/24dinitrotoluenereport411.pdf http://www.inchem.org/documents/iarc/vol65/dinitrotoluene.html http://inchem.org/documents/sids/sids/121142.html US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels Beagle dogs were administered 0,0.2, 1.5, or 10 mg.kg 2,4-DNT in capsules for up to 24 months. Methemoglobinemia and Heinz bodies were observed in dogs fed 1.5 mg/kg. Biliary hyperplasia and neurotoxicity (paralysis and cerebellar lesions) were also noted at this dose. No testicular degeneration was observed up to 10 mg.kg 2,4-DNT Toxicological Profile for 2,4- and 2,6-Dinitrotoluene December 1998 and ATSDR Minimal Risk Levels (MRLs) December 2008 http://www.atsdr.cdc.gov/toxprofiles/tp109.html http://www.atsdr.cdc.gov/mrls/ USEPA Health Advisors Groups of beagle dogs (6/sex/dose) were fed 2,4-DNT in gelatin capsules at 0, 0.2, 1.5, or 10 mg/kg/day. Neurotoxicity, Heinz bodies and biliary tract hyperplasia Drinking Water Health Advisories 2006 Edition and Drinking Water Health Advisory for 2,4-Dinitrotoluene and 2,6-Dinitrotoluene http://www.epa.gov/waterscience/criteria/drinking/dwstandards www.epa.gov/safewatr/ccl/pdf/DNTs.pdf USEPA Integrated Risk Information System (IRIS) Groups of beagle dogs (6/sex/dose) were fed 2,4-DNT in gelatin capsules at 0, 0.2, 1.5, or 10 mg/kg/day. Neurotoxicity, Heinz bodies and biliary tract hyperplasia IRIS 2,4-Dinitrotoluene http://www.epa.gov/ncea/iris/subst/0524.htm TDI inhal Organisation Description Response Reference Web link ID oral Organisation Description Response Reference Web link ID inhal Organisation Description Response Reference Web link Page 2 of 2 EIC proforma 2,4-dinitrotoluene.xls 28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 2,4-Dinitrotoluene CAS 121-14-2 Assessor A: J Lymer, Wardell Armstrong Assessor B: D, Brooks, Sirius Final review: Panel/SF Date 13/03/2009 Date 14/04/2009 Date 28/08/2009 MDI Recommended MDIoral Units 0 ug day-1 Justification: No data, background exposure assumed negligible in comparison to HCV. HCV is equivalent to drinking water concentration of 70μg/L based on a 70kg adult consuming 2L/day. Organisation Date Media Value Units Description Reference Web link MDI Recommended MDIinh Units Justification: No data, likely to be negligible 0 ug day-1 Organisation Date Media Value Units Description Reference Web link Page 1 of 1 EIC proforma 2,4-dinitrotoluene.xls 28/08/2009
Page 1 and 2:
www.esdat.net Esdat Environmental D
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64: www.esdat.net Esdat Environmental D
Page 103 and 104: 1,3,5-Trimethylbenzene CAS 108-67-8
Page 113: www.esdat.net Esdat Environmental D
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321:
show all

Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

Create successful ePaper yourself

Delete template?

Save as template?