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2,4-Dinitrotoluene
TDI oral
Organisation
Description Target organ/Critical Effect Reference Web link
European Chemicals Bureau (ECB)
International Agency for Research on
Cancer (IARC)
Organisation for Economic Co-operation
and Development (OECD) Screening
Information Data Set (SIDS) for High
Production Volume Chemicals
N/A
2,4- and 2,6-Dinitrotoluenes are possibly
carcinogenic to humans (Group 2B).
the critical effects for risk characterisation derived from the 24-month
rat study were presence of hyperplastic foci in the liver and atrophy of
seminiferous tubules.
No teratogenic effects were recorded and impairment of fertility were
observed at doses which also cause other effects.
European Union Risk Assessment Report 2,4-dinitrotoluene
2,4-Dinitrotoluene
ecb.jrc.ec.europa.eu/documents/Existing-
Chemicals/RISK_ASSESSMENT/REPORT/24dinitrotoluenereport411.pdf
http://www.inchem.org/documents/iarc/vol65/dinitrotoluene.html
http://inchem.org/documents/sids/sids/121142.html
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
Beagle dogs were administered 0,0.2, 1.5, or 10
mg.kg 2,4-DNT in capsules for up to 24 months.
Methemoglobinemia and Heinz bodies were observed in dogs fed 1.5
mg/kg. Biliary hyperplasia and neurotoxicity (paralysis and cerebellar
lesions) were also noted at this dose. No testicular degeneration was
observed up to 10 mg.kg 2,4-DNT
Toxicological Profile for 2,4- and 2,6-Dinitrotoluene December 1998 and
ATSDR Minimal Risk Levels (MRLs) December 2008
http://www.atsdr.cdc.gov/toxprofiles/tp109.html
http://www.atsdr.cdc.gov/mrls/
USEPA Health Advisors
Groups of beagle dogs (6/sex/dose) were fed
2,4-DNT in gelatin capsules at 0, 0.2, 1.5, or 10
mg/kg/day.
Neurotoxicity, Heinz bodies and biliary tract hyperplasia
Drinking Water Health Advisories
2006 Edition and Drinking Water Health Advisory
for 2,4-Dinitrotoluene and 2,6-Dinitrotoluene
http://www.epa.gov/waterscience/criteria/drinking/dwstandards
www.epa.gov/safewatr/ccl/pdf/DNTs.pdf
USEPA Integrated Risk Information System
(IRIS)
Groups of beagle dogs (6/sex/dose) were fed
2,4-DNT in gelatin capsules at 0, 0.2, 1.5, or 10
mg/kg/day.
Neurotoxicity, Heinz bodies and biliary tract hyperplasia IRIS 2,4-Dinitrotoluene http://www.epa.gov/ncea/iris/subst/0524.htm
TDI inhal
Organisation
Description Response Reference Web link
ID oral
Organisation
Description Response Reference Web link
ID inhal
Organisation
Description Response Reference Web link
Page 2 of 2 EIC proforma 2,4-dinitrotoluene.xls 28/08/2009