Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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2,4-Dimethylphenol CAS Number: 105-67-9 Assessor A: D Brooks, Sirius Assessor B: J Lymer, Wardell Armstrong Final Review: Panel/SF
Date 01/04/2009
Date 14/04/2009
Date 28/08/2009
Oral
Dermal
Inhalation
Combine Oral
and Inhalation
TDIs
Justification
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Yes Yes Yes
No No No
NR
Insufficient evaluation to determine with respect
to a human carcinogen - TDIoral applied to oral,
dermal and inhalation routes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
No No No
No No No
Inadequate data available to derive inhalation
HCV
TDI oral
Recommended
TDIoral Units
20 ug.kg-1.d-1
Justification
Only available value from reliable source (IRIS) chosen
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
USEPA Integrated Risk Information System
(IRIS)
Confidence
rating
Basis Value Units UF UF description
http://epa.gov/iris/ 01/11/1990 13/03/2009 Oral RfD 0.02 mg/kg/day 20 Medium-Low NOAEL 50 mg/kg/day 3000 An uncertainty factor of 3000 was
established: 10 each for inter- and
intraspecies variability and 30 for lack
of chronic toxicity data, data in a
second species and
reproductive/developmental studies
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
http://rais.ornl.gov/tox/unauthorized.shtml 27/06/2007 15/07/2009 Subchronic Oral Rfd 0.05 mg/kg/day 50 NOAEL 50 mg/kg/day 1000 10 for interspecies; 10 for intraspecies;
10 for database insufficiencies
TDI inhal
Recommended
TDIinhal
N/A
Units
Justification
Inadequate data available to derive inhalation HCV
Organisation Last Updated Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
ID oral
Recommended
IDoral
Units
Justification
Confidence
rating
Basis Value Units UF UF description
Organisation Last Updated Non threshold
effects
Basis
Health criteria
type
Value Units Confidence rating Basis
ID inhal
Recommended
IDinhal
Units
Justification
Organisation Last Updated Non threshold
effects
Basis
Health criteria
type
Value Units Confidence rating Basis
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EIC proforma 2,4-dimethylphenol.xls28/08/2009