Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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1-Methylnaphthalene<br />
TDI oral<br />
Organisation<br />
Description Target organ/Critical Effect Reference Web link<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATSDR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
81-week oral study of male and female mice<br />
provide available carcinogenicity assay <strong>for</strong> 1-<br />
methylnaphthalene.<br />
A chronic screening-value RfD of 7E-3 mg/kgday<br />
based on pulmonary alveolar proteinosis in<br />
mice (Murata et al., 1993) is derived by dividing<br />
the LOAEL of 71.6 mg/kg-day by a composite<br />
uncertainty factor (UF) of 10,000, which<br />
includes factors of 10 <strong>for</strong> extrapolating from a<br />
LOAEL to a NOAEL, 10 <strong>for</strong> interspecies<br />
extrapolation 10 <strong>for</strong> interindividual variability<br />
Chronic-duration study of 1-methylnaphthalene<br />
in the diet<br />
Pulmonary alveolar proteinosis in female<br />
mice<br />
Pulmonary alveolar proteinosis in female<br />
mice<br />
Appendix A of Superfund <strong>Health</strong> <strong>Risk</strong> Technical Support Center, National http://www.epa.gov/iris<br />
Center <strong>for</strong> Environmental <strong>Assessment</strong>, Office of Research and Development,<br />
U.S. Environmental Protection Agency, Cincinnati, OH 45268Provisional Peer<br />
Reviewed Toxicity Values <strong>for</strong> 1-Methylnaphthalene (CASRN 90-12-0)<br />
Murata et al. 1993<br />
http://www.atsdr.cdc.gov/toxprofiles/tp67.pdf<br />
TDI inhal<br />
Organisation<br />
Description Response Reference Web link<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
http://www.epa.gov/iris<br />
ID oral<br />
Organisation<br />
Description Response Reference Web link<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
81-week oral study of male and female mice<br />
provide available carcinogenicity assay <strong>for</strong> 1-<br />
methylnaphthalene (Mutata et al., 1993)<br />
Increased incidences of lung adenomas or<br />
carcinomas (combined)<br />
Superfund <strong>Health</strong> <strong>Risk</strong> Technical Support Center, National Center <strong>for</strong><br />
Environmental <strong>Assessment</strong>, Office of Research and Development, U.S.<br />
Environmental Protection Agency, Cincinnati, OH 45268Provisional Peer<br />
Reviewed Toxicity Values <strong>for</strong> 1-Methylnaphthalene (CASRN 90-12-0)<br />
http://www.epa.gov/iris<br />
ID inhal<br />
Organisation<br />
Description Response Reference Web link<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
http://www.epa.gov/iris<br />
Page 2 of 2 EIC pro<strong>for</strong>ma 1-methylnaphthalene.xls 28/08/2009
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