Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Contaminant Name: 1,3,5 Trimethylbenzene CAS Number: 108-67-8 Assessor A: Mathew Rouge Assessor B: Gareth Wills Final Review: Panel/SF<br />
Date: Mar-09 Date: Apr-09 Date:<br />
28/08/2009<br />
Apply TDIoral to exposure routes<br />
Apply IDoral to exposure routes<br />
Apply TDIinh to exposure routes<br />
Apply IDinh to exposure routes<br />
Oral<br />
Inhalation<br />
Dermal<br />
No No No<br />
No No No<br />
No No No<br />
No No No<br />
Combine Oral Justification<br />
and Inhalation<br />
TDIs<br />
Insufficient data with sufficient detail in derivation<br />
to derive HCV. No in<strong>for</strong>mation available regarding<br />
carcinogenicity<br />
N/A<br />
Insufficient data with sufficient detail in derivation<br />
to derive HCV. No in<strong>for</strong>mation available regarding<br />
carcinogenicity<br />
TDI oral<br />
Recommended<br />
TDIoral Units<br />
Justification<br />
none ug.kg-1.d-1 No recommended TDIoral. Insufficient data with detail on derivation to derive TDIoral<br />
Organisation Web Link Last Updated Date Web Checked <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg-<br />
1.d-1<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
Office of Environmental <strong>Health</strong> Hazard<br />
<strong>Assessment</strong><br />
Confidence<br />
rating<br />
Basis Value Units UF UF description Study type<br />
http://rais.ornl.gov/tox/unauthorized.shtml 2009 Jul-09 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a<br />
http:oehha.ca.gov/water/pals/124135tmb.ht<br />
ml<br />
2001 Jul-09 RfD 47.66 ug/kg bw/day 47.66 Not provided NOAEL 143 mg/kg-day 3000 10 <strong>for</strong> interspecies extrapolation, 10<br />
<strong>for</strong> extrapolation from subchronic to<br />
chronic study, 10 <strong>for</strong> human<br />
variability, 3 <strong>for</strong> database deficiencies.<br />
Subchronic rat<br />
study<br />
<strong>Risk</strong> <strong>Assessment</strong> In<strong>for</strong>mation System http://rais.ornl.gov/tox/rap_toxp.shtml 2008 Mar-09 RfD 50 ug/kg bw/day 50 Low NOAEL Not provided Not provided 3000 Not provided Not provided<br />
Texas Commission on Environmental<br />
Quality<br />
http://www.tceq.state.tx.us/remediation/rrr.<br />
html<br />
2008 Mar-09 RfD 50 ug/kg bw/day 50 Not provided Not provided Not provided Not provided Not provided Not provided Not provided<br />
TDI inhal<br />
Recommended<br />
TDIoral Units<br />
Justification<br />
none ug.kg-1.d-1 No recommended TDIinh. Insufficient data with detail on derivation to derive TDIinhalation<br />
Organisation Last Updated <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg-<br />
1.d-1<br />
<strong>Health</strong> and Safety Executive (HSE) http://www.hse.gov.uk/ 2007 Mar-09 Workplace Exposure<br />
Limit<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
125 (All<br />
trimethylbenzen<br />
e isomers)<br />
mg/m3<br />
35714.29 ug/kg<br />
bw/day<br />
Confidence<br />
rating<br />
Basis Value Units UF UF description Study type<br />
Not provided Not provided Not provided Not provided Not provided Not provided Not provided<br />
http://rais.ornl.gov/tox/unauthorized.shtml 2009 Jul-09 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a<br />
<strong>Risk</strong> <strong>Assessment</strong> In<strong>for</strong>mation System http://rais.ornl.gov/tox/rap_toxp.shtml 2008 Mar-09 RfC 6.00E-03 mg/m3 1.71 ug/kg bw/d low NOAEL 18 mg/m3 3000 No details provided <strong>Human</strong> study<br />
Texas Commission on Environmental<br />
Quality<br />
http://www.tceq.state.tx.us/remediation/rrr.<br />
html<br />
2008 Mar-09 RfC 6.00E-03 mg/m3 1.71 ug/kg bw/d Not provided Not provided Not provided Not provided Not provided Not provided Not provided<br />
ID oral<br />
Recommended<br />
IDoral<br />
none<br />
Units<br />
ug.kg-1.d-1<br />
Justification<br />
No in<strong>for</strong>mation available regarding carcinogenicity<br />
Organisation Web Link Last Updated Date Web Checked Non threshold<br />
effects<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
Basis<br />
<strong>Health</strong> criteria<br />
type<br />
Value Units Confidence rating<br />
Basis<br />
Study type<br />
http://rais.ornl.gov/tox/unauthorized.shtml 2009 Jul-09 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a<br />
ID inhal<br />
Recommended<br />
IDinhal<br />
none<br />
Units<br />
ug.kg-1.d-1<br />
Justification<br />
No in<strong>for</strong>mation available regarding carcinogenicity<br />
Organisation Web Link Last Updated Date Web Checked Non threshold<br />
effects<br />
Basis<br />
<strong>Health</strong> criteria<br />
type<br />
Value Units Confidence rating<br />
Basis<br />
Study type<br />
(Page 1 of 2) (EIC pro<strong>for</strong>ma 1,3,5-trimethylbenzene.xls 28/08/2009)
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