2011-2012 Bulletin – PDF - SEAS Bulletin - Columbia University

systems are treated next (dominant forces in
colloidal systems, flocculation, preparation and
manipulation of colloidal systems) followed by a
discussion of self-organizing surfactant systems
(architecture of surfactants, micelles and
surfactant membranes, phase behavior).
CHEN E4640y Polymer surfaces and
interfaces
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisite: CHEN E4620 or consent of
instructor. A fundamental treatment of the
thermodynamics and properties relating to
polymer surfaces and interfaces. Topics include
the characterization of interfaces, theoretical
modeling of interfacial thermodynamics and
structure, and practical means for surface
modification.
CHEN E4645x Inorganic polymers, hybrid
materials, and gels
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisite: Organic chemistry. The focus of the
first art of the course, taught by Prof. Mark is on
the preparation, characterization, and applications
of inorganic polymers, with a heavy emphasis on
those based on main-group elements. Main topics
are characterization methods, polysiloxanes,
polysilanes, polyphosphazenes, ferrocenebased
polymers, other phosphorous-containing
polymers, boron-containing polymers, preceramic
inorganic polymers, and inorganic-organic hybrid
composites. The focus of the second part of the
course, taught by Prof. Koberstein is on gels,
both physical and chemical. Topics will include
gel chemistry, including epoxies, polyurethanes,
polyesters, vinyl esters and hydrogels, as well as
theoretical methods used to characterize the gel
point and gel properties.
CHEN E4660y Biochemical engineering
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisite: BMEN E4001 or the equivalent.
Engineering of biochemical and microbiological
reaction systems. Kinetics, reactor analysis, and
design of batch and continuous fermentation and
enzyme processes. Recovery and separations in
biochemical engineering systems.
CHEN E4680x Soft materials laboratory
3 pts. Lect/lab: 3. Not offered in 2011–2012.
Prerequisites: Two years of undergraduate
science courses and the instructors’ permission.
Corequisites: Limited to 15 students.
Covers modern characterization methods
for soft materials (polymers, complex fluids,
biomaterials). Techniques include differential
scanning calorimetry, dynamic light scattering,
gel permeation chromatography, rheology, and
spectroscopic methods. Team-taught by several
faculty and open to graduate and advanced
undergraduate students. Lab required.
CHEN E4700x Principles of genomic
technologies
3 pts. Lect: 3. Professor Ju.
Prerequisites: Undergraduate-level biology,
organic chemistry, and instructor’s permission.
Chemical and physical aspects of genome
structure and organization, genetic information
flow from DNA to RNA to protein. Nucleic acid
hybridization and sequence complexity of DNA
and RNA. Genome mapping and sequencing
methods. The engineering of DNA polymerase
for DNA sequencing and polymerase chain
reaction. Fluorescent DNA sequencing and
high-throughput DNA sequencer development.
Construction of gene chip and micro array for
gene expression analysis. Technology and
biochemical approach for functional genomics
analysis. Gene discovery and genetics database
search method. The application of genetic
database for new therapeutics discovery.
CHEN E4740x Biological transport and rate
phenomena, II
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisites: Any two of the following:
CHEN E3110; BIOL C2005; CHEN E3210 or
BMCH E3500. Analysis of transport and rate
phenomena in biological systems and in the
design of biomimetic transport-reaction systems
for technological and therapeutic applications.
Modeling of homogeneous and heterogeneous
biochemical reactions. The Bases of biological
transport: roles of convection, ordinary diffusion,
forced diffusion. Systems where reaction and
transport interact strongly. Applications to natural
and artificial tissue beds, tumor modeling,
controlled release, natural and artificial organ
function.
CHEN E4750x The genome and the cell
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisites: BIOL C2005, MATH E1210
The utility of genomic information lies in its
capacity to predict the behavior of living cells in
physiological, developmental, and pathological
situations. The effect of variations in genome
structure between individuals within a species,
including those deemed healthy or diseased,
and among species, can be inferred statistically
by comparisons of sequences with behaviors,
and mechanistically, by studying the action of
molecules whose structure is encoded within
the genome. This course examines known
mechanisms that elucidate the combined effect
of environmental stimulation and genetic makeup
on the behavior of cells in homeostasis, disease
states, and during development, and includes
assessments of the probable effect of these
behaviors on the whole organism. Quantitative
models of gene translation and intracellular
signal transduction will be used to illustrate
switching of intracellular processes, transient and
permanent gene activation, and cell commitment,
development, and death.
CHEN E4760y Genomics sequencing
laboratory
3 pts. Lect: 1. Lab: 2. Professor Ju.
Prerequisites: Undergraduate level biology,
organic chemistry, and instructor’s permission.
The chemical, biological and engineering
principles involved in the genomics sequencing
process will be illustrated throughout the course
for engineering students to develop the hands-on
skills in conducting genomics research.
CHEN E4800x Protein engineering
3 pts. Lect: 3. Professor Banta.
Prerequisite: CHEN E4230, may be taken
concurrently, or the instructor’s permission.
Fundamental tools and techniques currently
used to engineer protein molecules. Methods
used to analyze the impact of these alterations
on different protein functions with specific
emphasis on enzymatic catalysis. Case studies
reinforce concepts covered, and demonstrate
the wide impact of protein engineering research.
Application of basic concepts in the chemical
engineering curriculum (reaction kinetics,
mathematical modeling, thermodynamics)
to specific approaches utilized in protein
engineering.
BMCH E4810y Artificial organs
3 pts. Lect: 3. Professor Leonard.
Analysis and design of replacements for the
heart, kidneys, and lungs. Specification and
realization of structures for artificial organ
systems.
CHEN E6050x Advanced electrochemistry
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisite: Instructor’s permission. An
advanced overview of the fundamentals of
electrochemistry, with examples taken from
modern applications. An emphasis is placed on
mass transfer and scaling phenomena. Principles
are reinforced through the development of
mathematical models of electrochemical
systems. Course projects will require computer
simulations. The course is intended for advanced
graduate students, conducting research involving
electrochemical technologies.
CHEE E6220y Equilibria and kinetics in
hydrometallurgical systems
3 pts. Lect: 3. Professor Duby.
Prerequisite: Instructor’s permission. An
advanced overview of the fundamentals of
electrochemistry, with examples taken from
modern applications. An emphasis is placed on
mass transfer and scaling phenomena. Principles
are reinforced through the development of
mathematical models of electrochemical
systems. Course projects will require computer
simulations. The course is intended for advanced
graduate students, conducting research involving
electrochemical technologies.
CHEE E6252y Applied surface and colloid
chemistry
3 pts. Lect: 2. Lab: 3. Professor Somasundaran.
Prerequisites: CHEN 4252. Applications
of surface chemistry principles to wetting,
flocculation, flotation, separation techniques,
catalysis, mass transfer, emulsions, foams,
aerosols, membranes, biological surfactant
systems, microbial surfaces, enhanced oil
recovery, and pollution problems. Appropriate
individual experiments and projects. Lab
required.
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engineering 2011–2012