2011-2012 Bulletin – PDF - SEAS Bulletin - Columbia University

BMEN E4420y Biomedical signal processing
and signal modeling
3 pts. Lect: 3. Professor Sajda.
Prerequisites: APMA E3101 and ELEN E3202
or instructor’s permission Fundamental concepts
of signal processing in linear systems and
stochastic processes. Estimation, detection, and
filtering methods applied to biomedical signals.
Harmonic analysis, auto-regressive model,
Wiener and Matched filters, linear discriminants,
and independent components. Methods are
developed to answer concrete questions on
specific data sets in modalities such as ECG,
EEG, MEG, ultrasound. Lectures accompanied
by data analysis assignments using MATLAB.
BMEN E4430x Principles of magnetic
resonance imaging
3 pts. Lect: 3. Instructor to be announced.
Prerequisites: APAM E3101, MATH E1210,
PHYS C1403 or instructors’ permission.
Fundamental principles of Magnetic Resonance
Imaging (MRI), including the underlying spin
physics and mathematics of image formation
with an emphasis on the application of MRI to
neuroimaging, both anatomical and functional.
The course examines both theory and
experimental design techniques.
MEBM E4439x Modeling and identification of
dynamic systems
3 pts. Lect: 3. Professor Chbat.
Prerequisites: APMA E2101, ELEN E3801 or
co-requisite EEME E3601, or permission of
instructor. Generalized dynamic system modeling
and simulation. Fluid, thermal, mechanical,
diffusive, electrical, and hybrid systems are
considered. Nonlinear and high order systems.
System identification problem and Linear
Least Squares method. State-space and noise
representation. Kalman Filter. Parameter
estimation via prediction-error and subspace
approaches. Iterative and bootstrap methods.
Fit criteria. Wide applicability: medical, energy,
others. Matlab and Simulink environments.
BMEN E4440y Physiological control systems
3 pts. Lect: 3. Professor Chbat.
Prerequisites: APMA E2101 and with instructor’s
approval or senior standing Dynamic system
modeling and simulation of cardiovascular,
respiratory, and thermoregulatory systems. Open
and closed physiological loops. Internal and
external controllers: baroreflex, chemoreflex, and
ventilator. Fundamentals of time and frequency
domain analyses and stability. Emulation of
normal and pathophysiological conditions.
Clinical relevance and decision support. MATLAB
and SIMULINK programming environments are
utilized.
BMEN E4450y Dental and craniofacial tissue
engineering
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisites: MSAE E3103, BMEN E4210, E4501,
or equivalent. Principles of dental and craniofacial
bioengineering, periodontal tissue engineering:
beyond guided tissue regeneration, craniofacial
regeneration by stem cells and engineered
scaffolds, biomaterials: Engineering approaches
in tissue regeneration, bone biology and
development: instructive cues for tissue engineers.
BMEN E4501x Tissue engineering, I:
biomaterials and scaffold design
3 pts. Lect: 3. Professor Hess.
Prerequisites: BIOL C2005-C2006; BMEN
E4001-E4002. An introduction to the strategies
and fundamental bioengineering design criteria
in the development of biomaterials and tissue
engineered grafts. Material structural-functional
relationships, biocompatibility in terms of material
and host responses. Through discussions,
readings, and a group design project, students
acquire an understanding of cell-material
interactions and identify the parameters critical
in the design and selection of biomaterials for
biomedical applications.
BMEN E4502y Tissue engineering, II:
biological tissue substitutes
3 pts. Lect: 3. Professor Hung.
Prerequisites: BIOL C2005-C2006, BMEN
E4001-E4002. An introduction to the strategies
and fundamental bioengineering design criteria
behind the development of cell-based tissue
substitutes. Topics include biocompatibility,
biological grafts, gene therapy-transfer, and
bioreactors.
BMEN E4540y Bioelectrochemistry
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisites: CHEM C3079 and C3443 or
equivalent. Application of electrochemical
kinetics to interfacial processes occurring in
biomedical systems. Basics of electrochemistry,
electrochemical instrumentation, and relevant
cell and electrophysiology reviewed. Applications
to interpretation of excitable and nonexcitable
membrane phenomena, with emphasis on
heterogeneous mechanistic steps. Examples
of therapeutic devices created as a result of
bioelectrochemical studies.
BMEN E4550x Micro- and nanostructures in
cellular engineering
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisites: BIOL W2005 and W2006 or
equivalent. Design, fabrication, and application
of micro-/nanostructured systems for cell
engineering. Recognition and response of
cells to spatial aspects of their extracellular
environment. Focus on neural, cardiac,
coculture, and stem cell systems. Molecular
complexes at the nanoscale.
BMEN E4560y Dynamics of biological
membranes
3 pts. Lect: 3. Not offered in 2011–2012.
Prerequisites: BIOL C2005, BMEN E4001 or
equivalent. The structure and dynamics of
biological (cellular) membranes are discussed,
with an emphasis on biophysical properties.
Topics include membrane composition, fluidity,
lipid asymmetry, lipid-protein interactions,
membrane turnover, membrane fusion, transport,
lipid phase behavior. In the second half of the
semester, students will lead discussions of
recent journal articles.
BMEN E4570x Science and engineering of
body fluids
3 pts. Lect: 3. Professor Matsuoka.
Prerequisites: General chemistry, organic
chemistry, and basic calculus. Body fluids as
a dilute solution of polyelectrolyte molecules
in water. Study of physical behavior as
affected by the presence of ions in surrounding
environments. The physics of covalent, ionic,
and hydrogen bonds are reviewed, in relation
to the structure/properties of the body fluid.
Selected physiological processes are examined
in physical-chemical terms for polymers.
BMEN E4590y BioMems: cellular and
molecular applications
3 pts. Lect: 3. Professor Sia.
Prerequisites: Chemistry CHEM C3443 or
CHEN C3545 or equivalent and MATH V1201.
Corequisite: BIOL W2005 or equivalent.
Topics include biomicroelectromechanical,
microfluidic, and lab-on-a-chip systems in
biomedical engineering, with a focus on cellular
and molecular applications. Microfabrication
techniques, biocompatibility, miniaturization
of analytical and diagnostic devices, highthroughput
cellular studies, microfabrication for
tissue engineering, and in vivo devices.
BMEN E4601y Cellular electricity
3 pts. Lect: 2. Lab: 1. Not offered in 2011–2012.
Bioelectricity of the cell membrane. Basis of cell
resting voltage, voltage changes that lead to the
action potential and electrical oscillations used
in sensing systems. Laboratory includes building
electronic circuits to measure capacitance of
artificial membranes and ion pumping in frog
skin. Lab required.
APBM E4650x Anatomy for physicists and
engineers
3 pts. Lect: 3. Instructor to be announced.
Prerequisites: Engineering or physics
background. A systemic approach to the study
of the human body from a medical imaging point
of view: skeletal, respiratory, cardiovascular,
digestive, and urinary systems, breast and
women’s issues, head and neck, and central
nervous system. Lectures are reinforced
by examples from clinical two- and threedimensional
and functional imaging (CT, MRI,
PET, SPECT, U/S, etc.).
BMME E4702x Advanced musculoskeletal
biomechanics
3 pts. Lect: 2.5. Lab: 0.5. Not offered in
2011–2012.
Advanced analysis and modeling of the
musculoskeletal system. Topics include
advanced concepts of 3D segmental kinematics,
musculoskeletal dynamics, experimental
measurements of joint kinematics and anatomy,
modeling of muscles and locomotion, multibody
joint modeling, introduction to musculoskeletal
surgical simulations.
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engineering 2011–2012