eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
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EUROINVENT 2013<br />
7.12.<br />
Title<br />
Authors<br />
Institution<br />
Patent no.<br />
Description EN<br />
Class no.<br />
Superb MSE: Potential Local Medicinal Herb As<br />
Analgesics Substitute For Morphine To Alleviate Pain<br />
Ahmad Wafiq Bin Abdullah & Teoh Hooi Eng<br />
Sultan Mohamad Jiwa Science Secondary School<br />
Patent Pending<br />
Mitragynine is the major constituent in the plant M.<br />
speciosa Korth (Rubiacea). In this study we investigated<br />
the antinociceptive activity of the crude methanolic<br />
extract in mice using hot plate test . Work was also<br />
carried out to investigate the possible mechanism of<br />
action using naloxone an <strong>op</strong>iod receptor antagonist.<br />
Prior to animal studies the mitragynine content in the<br />
methanolic extract was determined in order to prepare<br />
the standardized extract which will be named as Superb<br />
MSE. Chromatograph profiling (GCMS) on different<br />
concentration of Superb Mitragyna speciosa Extract<br />
(Superb MSE) was analysed and the results showed<br />
that the mitragynine content was only 1.76%. As for<br />
the animal tests, superb MSE (200 mg/kg) shows<br />
significant analgesic affect, and the extract effect was<br />
blocked by naloxone, a nonselective and pure <strong>op</strong>iod<br />
antagonist thus suggesting the involvement of central<br />
<strong>op</strong>iod system in mediating an antinociceptive activity.<br />
To conclude, this study proved that M. speciosa Korth<br />
contains mitragynine which can act as analgesic drug<br />
for treatment of severe pain. In addition this<br />
standardized extract could be considered as a substitute<br />
drug for morphine in pain management In view of this<br />
work , the government should reconsider the potential<br />
use of ketum in chronic pain management an thus the<br />
government should re-evaluate the usefulness of ketum<br />
in medical practice.<br />
4. Medicine - Health Care - Cosmetics<br />
7.13.<br />
Title<br />
Authors<br />
Institution<br />
Patent no.<br />
LEO As An Eco-Saver<br />
Azra Zulaikha binti Haris, Iyliana Hiylda Fitri binti<br />
Haron<br />
TunkuKurshiah College<br />
Patent Pending<br />
INTERNATIONAL EXHIBITS<br />
69