eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi

EUROINVENT 2013
7.12.
Title
Authors
Institution
Patent no.
Description EN
Class no.
Superb MSE: Potential Local Medicinal Herb As
Analgesics Substitute For Morphine To Alleviate Pain
Ahmad Wafiq Bin Abdullah & Teoh Hooi Eng
Sultan Mohamad Jiwa Science Secondary School
Patent Pending
Mitragynine is the major constituent in the plant M.
speciosa Korth (Rubiacea). In this study we investigated
the antinociceptive activity of the crude methanolic
extract in mice using hot plate test . Work was also
carried out to investigate the possible mechanism of
action using naloxone an opiod receptor antagonist.
Prior to animal studies the mitragynine content in the
methanolic extract was determined in order to prepare
the standardized extract which will be named as Superb
MSE. Chromatograph profiling (GCMS) on different
concentration of Superb Mitragyna speciosa Extract
(Superb MSE) was analysed and the results showed
that the mitragynine content was only 1.76%. As for
the animal tests, superb MSE (200 mg/kg) shows
significant analgesic affect, and the extract effect was
blocked by naloxone, a nonselective and pure opiod
antagonist thus suggesting the involvement of central
opiod system in mediating an antinociceptive activity.
To conclude, this study proved that M. speciosa Korth
contains mitragynine which can act as analgesic drug
for treatment of severe pain. In addition this
standardized extract could be considered as a substitute
drug for morphine in pain management In view of this
work , the government should reconsider the potential
use of ketum in chronic pain management an thus the
government should re-evaluate the usefulness of ketum
in medical practice.
4. Medicine - Health Care - Cosmetics
7.13.
Title
Authors
Institution
Patent no.
LEO As An Eco-Saver
Azra Zulaikha binti Haris, Iyliana Hiylda Fitri binti
Haron
TunkuKurshiah College
Patent Pending
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