eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi

EUROINVENT 2013
41.1.
Title
Authors
Biotehnos S.A.
The development of phytotherapic products with action
against cutaneous inflammatory disturbances – a genuine
application of the new biotechnological infrastructure of
R&D from Biotehnos
Olariu Laura Zglimbea Lenuta, Dumitriu Brandusa, Ene
Manuela Diana, Nita Roxana Andreea, Dinca Gabriela
Biotehnos S.A.
Institution
Patent no. A00618/ 23.08.2012, 922/ 22.08.2012
Description
Class
Biotehnos - a Romanian company - has managed to develop in
three years a R&D infrastructure at international standards, thus
implementing its own original concept of interrelationships:
Research - Application - Capitalization. As a consequence of
Biotehnos R&D infrastructure development (acquisitions of LC-
MS, RT-PCR, analysing system for transdermal preparations,
irradiation system for bioanalysis, among others) there were
obtained several phytherapic products with cumulative dermal
restructuring and antiinflammatory actions for treatment of
various pathophysiological manifestations such as cutaneous
tissue cellulitis, peripheral edema, dark circles.
Original combination of bioactive components from various
plants meant for these phytherapic products’ development
determined the integration of the obtained results into a patent
that brings in the pooling of stimulating dermal restructuring
actions given by the cellular and protein turn-over and the
adhesion process cell - extracellular matrix, the sunscreen
effect by inducing cellular protection against apoptosis, together
with antioxidant, anti-inflammatory and anti-angiogenic effects
against UV radiation, anti-vascular inflammation through the
inhibition of pro-inflammatory cytokines IL6 and IL8 and
monocyte - endothelium adhesion molecules overexpression
(ICAM and VCAM) and, finally, the anti-vascular
permeability through VEGF factor inhibition. All these effects
are evidenced by specific tests for each one in part.
The input in Biotehnos’ biotechnology research infrastructure
was made on the basis of the project POS 275 / CNRS 6009
CTR 74/2009, while the patent development was made in the
frame of the project POS 383 / CNRS 6009 CTR 107/2010.
4. Medicine - Health Care - Cosmetics
NATIONAL
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