eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
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EUROINVENT 2013<br />
20.3.<br />
Title EN<br />
Authors<br />
Institution<br />
Description<br />
EN<br />
Class<br />
20.4.<br />
Title EN<br />
Authors<br />
Institution<br />
Description<br />
EN<br />
Antituberculosis activity of new indolizinylpyridinium<br />
quaternary salts<br />
Ramona Danac, Ionel Mangalagiu<br />
“Al. I. Cuza” University, Faculty of Chemistry<br />
Indolizine is an aromatic 10π-electron system and<br />
constitutional isomer of 1-H indol which due to its special<br />
electronic structure has long drawn much theoretical interest.<br />
Besides, indolizine derivatives have been found to possess a<br />
variety of biological activities such as anti-inflammatory,<br />
antiviral, analgesic and antitumor activities. The aim of this<br />
work was to synthesize new indolizinyl-pyridinium<br />
quaternary salts and to use them in antituberculosis testing.<br />
Thus, five new compounds were obtained using pyridyl<br />
indolizines as starting materials, and one was tested and<br />
found to possess a very good antituberculosis activity.<br />
X. Innovative Researches<br />
Title Synthesis and Antibacterial Pr<strong>op</strong>erties of<br />
ZnO/Clin<strong>op</strong>tilolit and TiO2/ZnTiO3/Clin<strong>op</strong>tilolite<br />
Powders<br />
Violeta Elena C<strong>op</strong>cia, Claudia Mihaela Hristodor, Simona<br />
Dunca, Reni Iordanova, Albena Bachvarova-Nedelcheva,<br />
Ion Sandu<br />
”Alexandru Ioan Cuza” University of Iași<br />
The purpose of this study was to estimate the antimicrobial activity<br />
of ZnO/clin<strong>op</strong>tilolit and ZnTiO3/clin<strong>op</strong>tilolite samples in solid<br />
media (agar plates) against Gram-negative Escherichia coli ATCC<br />
25922 and Gram-positive Staphylococcus aureus ATCC 25923.<br />
Samples of clin<strong>op</strong>tilolite rich tuff (from Beli Plast deposit in<br />
Eastern Rhod<strong>op</strong>es, Bulgaria) treated with oxalic acid were obtained.<br />
The ZnO and TiO2/ZnTiO3 were additionally incorporated into the<br />
clin<strong>op</strong>tilolite samples.<br />
The structure, morphology and elemental composition of the pretreated<br />
clin<strong>op</strong>tilolite samples were characterized by XRD, SEM and<br />
EDX analysis. The antibacterial activity was investigated by<br />
exposing Escherichia coli (E. coli) and Staphylococcus aureus (S.<br />
aureus) in nutritive media to the ZnO, TiO2/ZnTiO3,<br />
ZnO/clin<strong>op</strong>tilolit and TiO2/ZnTiO3/clin<strong>op</strong>tilolite samples. A strong<br />
bactericidal action of both samples against E. coli and S. aureus was<br />
observed. Moreover, the TiO2/ZnTiO3/clin<strong>op</strong>tilolite sample<br />
NATIONAL<br />
154
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