eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
EUROINVENT 2013<br />
20.2.<br />
Title EN<br />
Authors<br />
Institution<br />
Description<br />
EN<br />
Class<br />
Synthesis of new azaheterocyclic compounds using ecofriendly<br />
methods<br />
Vasilichia Antoci, Dorina Mantu, Gheorghita Zbancioc,<br />
Ionel I. Mangalagiu<br />
“Al.I. Cuza” University, Faculty of Chemistry<br />
Ultrasound (US) irradiation, during the last decades, has<br />
became an increasingly valuable tool in organic chemistry,<br />
since it is a versatile and facile technique applicable to a<br />
large variety of syntheses. In particular, for the chemistry of<br />
nitrogen heterocycles, literature data indicates that Huisgen<br />
[3+2] dipolar cycloaddition has been done under ultrasound<br />
irradiation in the class of nitrogen ylides, except for the<br />
cycloimmonium ylides, our group being the first one<br />
investigating this aspect.<br />
We desired to obtained new azaheterocyclic compounds,<br />
using eco-friendly synthesis. In this order we synthesized<br />
new azaheterocyclic compounds with acet<strong>op</strong>henonic chain,<br />
using a general and straightforward strategy (quaternization<br />
and cycloaddition reactions) under classical conditions and<br />
nonconventional methods (ultrasounds irradiation).<br />
Ultrasound assisted reactions were carried out using two<br />
different reactors: Sonics (Sonics VCX-130, USA), with a<br />
nominal power of 130W and Bandelin (Son<strong>op</strong>uls GM 3200),<br />
with a nominal power of 200W.<br />
The structure of compounds was proved by elemental and<br />
spectral analysis [IR, 1 H NMR, 13 C NMR, 2D-COSY, 2D-<br />
HETCOR (HMQC), long range 2D-HETCOR (HMBC)].<br />
A comparative study classical vs US was done.<br />
Financial support was provided by the project PN-II-DE-<br />
PCE-2011-3-0038, no.268/05.10.2011.<br />
X. Innovative Researches<br />
NATIONAL<br />
153