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EUROINVENT 2013
20.2.
Title EN
Authors
Institution
Description
EN
Class
Synthesis of new azaheterocyclic compounds using ecofriendly
methods
Vasilichia Antoci, Dorina Mantu, Gheorghita Zbancioc,
Ionel I. Mangalagiu
“Al.I. Cuza” University, Faculty of Chemistry
Ultrasound (US) irradiation, during the last decades, has
became an increasingly valuable tool in organic chemistry,
since it is a versatile and facile technique applicable to a
large variety of syntheses. In particular, for the chemistry of
nitrogen heterocycles, literature data indicates that Huisgen
[3+2] dipolar cycloaddition has been done under ultrasound
irradiation in the class of nitrogen ylides, except for the
cycloimmonium ylides, our group being the first one
investigating this aspect.
We desired to obtained new azaheterocyclic compounds,
using eco-friendly synthesis. In this order we synthesized
new azaheterocyclic compounds with acetophenonic chain,
using a general and straightforward strategy (quaternization
and cycloaddition reactions) under classical conditions and
nonconventional methods (ultrasounds irradiation).
Ultrasound assisted reactions were carried out using two
different reactors: Sonics (Sonics VCX-130, USA), with a
nominal power of 130W and Bandelin (Sonopuls GM 3200),
with a nominal power of 200W.
The structure of compounds was proved by elemental and
spectral analysis [IR, 1 H NMR, 13 C NMR, 2D-COSY, 2D-
HETCOR (HMQC), long range 2D-HETCOR (HMBC)].
A comparative study classical vs US was done.
Financial support was provided by the project PN-II-DE-
PCE-2011-3-0038, no.268/05.10.2011.
X. Innovative Researches
NATIONAL
153