eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi

EUROINVENT 2013
„Alexandru Ioan Cuza” University of Iasi
20.1.
Title EN
Authors
Institution
Description
EN
Class
NMR and X-ray complete characterization of
some unexpected fused azaheterocycles
Dorina Mantu, 1 Vasilichia Antoci, 1 Costel Moldoveanu 1 ,
Sergiu Sova 2 , Ionel I. Mangalagiu 1
1 “Al. I. Cuza” University of Iasi, Faculty of Chemistry
2
“Petru Poni” Institute of Macromolecular Chemistry
Heterocylic compounds in general and nitrogen heterocycles in
particular, are the basis of many significant pharmaceuticals,
physiologically-active natural products and synthetic
compounds. Among them, the 1,2-diazine derivatives are
important constituents in some drugs already in use for different
human diseases or agrochemical products.
In this respect, one of the main objectives of our research
activity was the synthesis of new hydrazides/hydrazones starting
from some N 2 -substituted pyridazin-3(2H)-ones and hydrazine
hydrate, by adapting the literature procedures. Thus, varying the
reactant ratio and using ethanol as solvent, we obtained the
desired hydrazides, but also some unexpected fused
azaheterocycles, as products of cyclocondensation reactions.
The structure of compounds was proved by spectral analysis
(IR, 1 H-NMR, 13 C-NMR) and X-ray diffraction (using a X-ray
diffractometer: Xcalibur, Eos diffractometer).
The newly obtained compounds are of practical interest as
biological-active compounds (the tests are ongoing), and also
those one bearing the amino marginal group could be used as
intermediates for cyclization processes, to obtain oxazole/
imidazole derivatives, known also as biological-active units and
ionic liquid compounds.
Financial support was provided by the project: PN-II-DE-
PCE-2011-3-0038, no. 268/05.10.2011.
X. Innovative Researches
NATIONAL
152