eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
eur op eanexhibitionofcreati vityandinnovation - Europe Direct Iasi
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8.60.<br />
Title<br />
EUROINVENT 2013<br />
Republic of Moldova<br />
Ministry of Health<br />
Institute of Mother And Child<br />
THE GENERALIZED MULTIFACTOR<br />
DIMENSIONALITY REDUCTION METHOD OF<br />
ASTHMA IN MOLDOVAN CHILDREN ON<br />
APPLICATION SOFTWARE GMDR (Generalized<br />
Multifactor Dimensionality Reduction)<br />
Olga CÎRSTEA, Ala COJOCARU, Liubov VASILOS<br />
Institute of Mother And Child<br />
Authors<br />
Institution<br />
Patent no. MD3433 26.07.2012<br />
Description EN<br />
Class no.<br />
The innovation relates to medicine especially for<br />
pediatry. The study results demonstrate that GMDR<br />
interaction model may work as a phenotype predictor<br />
based on the genetic information to improve the clinical<br />
diagnosis.<br />
Asthma is a multifactorial disease caused by<br />
numerous genetic and environmental factors, and their<br />
interactions. The generalized multifactor dimensionality<br />
reduction method (GMDR software, version Beta 0.9)<br />
pr<strong>op</strong>oses a combinatorial approach for genetic data<br />
analysis that unifies biological, statistical and<br />
evolutionary theories. A number of polymorphisms in<br />
nine asthma candidate genes (GSTТ1, GSTM1, GSTP1,<br />
NAT2, IL-4, IL-4Rα, TNFα, NOS1 and CC16) were<br />
evaluated and the combination of genes that increases<br />
3.6 folds the risk of childhood asthma devel<strong>op</strong>ment<br />
(OR=3,61; CI 95% 1,45-8,99; p
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