njit-etd2003-081 - New Jersey Institute of Technology

njit-etd2003-081 - New Jersey Institute of Technology njit-etd2003-081 - New Jersey Institute of Technology

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235 attempt by adjusting the threshold of the correlation coefficients would provide a better and more defined group of clusters. However, this would defeat the purpose of blind separation and classification. The COPD assignment of the 47 COPD and 8 normal subjects are presented in Table 5.10. When compared to the clinical classification using FEV1 over FVC data the PCA-CA classification technique produces very high accuracy results. It has been shown to separate the COPD from the normal population with 100% accuracy. It can also classify the COPD population into "at risk", "mild", "moderate" and "severe" stages with 100%, 90%, 88% and 100% accuracy respectively. As a result, cluster and principal component analysis can be used to separate COPD and normal subjects and can be used successfully in COPD severity classification. Figure 5.63 Separation of normal (Red) from COPD subjects (Blue/Green).

236 Figure 5.64 Severity classification of normal and COPD subjects. (Normal: blue circle, At Risk: green star, Mild: cyan pentagon, Moderate: magenta square and Severe: red diamond). Table 5.10 Summary of Normal-COPD Severity Classification Stage Clinical PCA-CA % Accuracy Severe 4 4 100.00 Moderate 17 15 88.23 Mild 18 20 90.00 At Risk 8 8 100.00 Normal 8 8 100.00

235<br />

attempt by adjusting the threshold <strong>of</strong> the correlation coefficients would provide a better<br />

and more defined group <strong>of</strong> clusters. However, this would defeat the purpose <strong>of</strong> blind<br />

separation and classification.<br />

The COPD assignment <strong>of</strong> the 47 COPD and 8 normal subjects are<br />

presented in Table 5.10. When compared to the clinical classification using FEV1 over<br />

FVC data the PCA-CA classification technique produces very high accuracy results. It<br />

has been shown to separate the COPD from the normal population with 100% accuracy.<br />

It can also classify the COPD population into "at risk", "mild", "moderate" and "severe"<br />

stages with 100%, 90%, 88% and 100% accuracy respectively. As a result, cluster and<br />

principal component analysis can be used to separate COPD and normal subjects and can<br />

be used successfully in COPD severity classification.<br />

Figure 5.63 Separation <strong>of</strong> normal (Red) from COPD subjects (Blue/Green).

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