njit-etd2003-081 - New Jersey Institute of Technology
njit-etd2003-081 - New Jersey Institute of Technology njit-etd2003-081 - New Jersey Institute of Technology
103 3.13.2.1 Open-loop Input Driven ARX Model. The Open-loop Input Driven ARX Model is shown in Figure 3.15. The inputs to the model are [54]: Respiration Vt(n). Systolic blood pressure, SBP(n) The output of the model is: Heart Rate, RR(n). Figure 3.15 Open-loop input driven ARX model. This figure shows an open-loop model-based approach that enables the dynamic effects of respiration and arterial systolic blood pressure on heart rate to be estimated in both COPD and normal subjects. This method is based on a two-compartment model of respiratory sinus arrhythmia (RSA), which includes a vagally mediated central component (h_rsa), and an arterial baroreflex (h_abr) component driven by both vagal and sympathetic systems. A parametric linear AutoRegressive representation with
104 eXogenous input (ARX) was used to estimate the impulse responses (IR) and transfer function (TF) of the two couplings in the model. A number of indexes derived from the IR's (peak magnitude, time of peak, delays) and TF's (gains and phases in the frequency bands of interest) were used for subsequence statistical analysis and the assessment of autonomic function. The two-compartment model of RSA in the Figure is described as an ARX representation by the equation. The coefficient of each polynomials (Bo A) were estimated from the data by least square minimization of the prediction error W The orders and the delays of the model were chosen by finding the model that minimized the cross-correlation of each input and the prediction error, as well as the Minimum Description Length (MDL) 3.13.2.2 Feedback Closed -loop ARX Model. In this section a more realistic physiological model involving baroreflex and feedback loop. The depolarization, and therefore contraction, of the ventricles is associated with the ejection of blood into the aorta during systole. If one made the assumption that the volume of ejected blood is roughly the same for each contraction, then the arterial pressure will only be a function of the timing of the contractions. If several contractions occur close together, arterial pressure builds, causing simultaneous stimulation and inhibition of the parasympathetic and sympathetic branches of the ANS, respectively, resulting in a decrease in the rate of depolarization of the SA nodal tissue. A cascade of contractions that occur further apart
- Page 81 and 82: 52 3.5 Covariance and Invariance Th
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- Page 97 and 98: 68 This condition forces that the w
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- Page 159 and 160: 130 The patients who underwent LVRS
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104<br />
eXogenous input (ARX) was used to estimate the impulse responses (IR) and transfer<br />
function (TF) <strong>of</strong> the two couplings in the model. A number <strong>of</strong> indexes derived from the<br />
IR's (peak magnitude, time <strong>of</strong> peak, delays) and TF's (gains and phases in the frequency<br />
bands <strong>of</strong> interest) were used for subsequence statistical analysis and the assessment <strong>of</strong><br />
autonomic function.<br />
The two-compartment model <strong>of</strong> RSA in the Figure is described as an ARX<br />
representation by the equation. The coefficient <strong>of</strong> each polynomials (Bo A) were<br />
estimated from the data by least square minimization <strong>of</strong> the prediction error W The<br />
orders and the delays <strong>of</strong> the model were chosen by finding the model that minimized the<br />
cross-correlation <strong>of</strong> each input and the prediction error, as well as the Minimum<br />
Description Length (MDL)<br />
3.13.2.2 Feedback Closed -loop ARX Model. In this section a more realistic<br />
physiological model involving baroreflex and feedback loop. The depolarization, and<br />
therefore contraction, <strong>of</strong> the ventricles is associated with the ejection <strong>of</strong> blood into the<br />
aorta during systole. If one made the assumption that the volume <strong>of</strong> ejected blood is<br />
roughly the same for each contraction, then the arterial pressure will only be a function<br />
<strong>of</strong> the timing <strong>of</strong> the contractions. If several contractions occur close together, arterial<br />
pressure builds, causing simultaneous stimulation and inhibition <strong>of</strong> the parasympathetic<br />
and sympathetic branches <strong>of</strong> the ANS, respectively, resulting in a decrease in the rate <strong>of</strong><br />
depolarization <strong>of</strong> the SA nodal tissue. A cascade <strong>of</strong> contractions that occur further apart