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njit-etd2003-081 - New Jersey Institute of Technology

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TABLE OF CONTENTS<br />

Chapter<br />

Page<br />

1 INTRODUCTION 1<br />

1.1 Scope <strong>of</strong> research 1<br />

1.2 Goals and Contributions 8<br />

1.3 Outline <strong>of</strong> the dissertation 12<br />

2 PHYSIOLOGY BACKGROUND 14<br />

2.1 Cardiovascular Systems and the Heart 14<br />

2.2 Blood Pressure 20<br />

2.3 Metabolic Function/Respiration 21<br />

2.4 The Nervous System 22<br />

2.4.1 The Autonomic Nervous System 23<br />

2.4.2 The Baroreflex Mechanism 27<br />

2.5 Heart Rate and Heart Rate Variability 29<br />

2.5.1 Physiology <strong>of</strong> changes in heart rate 29<br />

2.5.2 Heart rate variability as a measure <strong>of</strong> Autonomic Function 31<br />

2.5.3 Baroreflex Response 32<br />

2.6 The Electrocardiogram (ECG) 34<br />

2.7 Chronic Obstructive Pulmonary Disease (COPD) 37<br />

2.7.1 Classification <strong>of</strong> COPD by severity 39<br />

3 ENGINEERING BACKGROUND 42<br />

3.1 Time-Frequency Distributions 43<br />

ix

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