Product Information Sheet (for US market only) - Lohmann Animal ...

Avian Vaccines
Convincing Advantages:
– 100% bursa-derived standard Gumboro
and variant Delaware E
– High titers of Reo
– Supreme protection of the offspring
– Designed for the needs of broiler breeders

Get strong protection
From an economic point of view, Infectious Bursal Disease (IBD), also
known as Gumboro Disease, is one of the most important poultry diseases
worldwide. It is a viral disease that affects the immune system of
poultry. Young chicks up to 6 weeks of life are most susceptible to the
virus, depending on their level of maternal immunity. Vaccinated breeders
transfer protective antibodies to their offspring. Therefore, it is recommended
to vaccinate breeders with an inactivated IBD vaccine before
start of production. This should induce high, uniform and long-lasting
antibody titers in the breeder birds, which will result in a high level of
protection in the offspring.
Leg problems and Malabsorption Syndrome in young birds justify all
the concern poultry producers have put on Reovirus (Reo) as a potential
cause of economic losses. Since chicks are most susceptible to Reo infections
during the first week of life, protection by maternal antibodies is
an obvious road to control. The best way to do this is to induce high and
uniform levels of immunity in the parent flocks by vaccinating them with
an inactivated Reo vaccine. Live vaccines are mainly used as primers to
increase the booster effect of the killed vaccine.
AviPro® 226 BTO2-REO will confer high titers of IBD antibodies to the vaccinated
parents, with the objective of transferring these antibodies to the
progeny. A high level of maternally-derived antibodies (MDA) is desired
in the offspring, to counter early challenges of Gumboro and Reo virus,
before a live vaccine may trigger a proper immune response. The inclusion
of a variant strain (Delaware E) on the vaccine combination will add
to the classical Gumboro strain, broadening the scope of protection.
– Designed for
broiler breeders
– Reliable protection
– High titers
Study
One hundred and forty pullets, 8 weeks of age were separated into three groups. All birds were
primed with a live intermediate strain of IBD and/or a live Reovirus vaccine administered via eye
drop. At 12 weeks of age, one group was vaccinated subcutaneously in the neck with a full dose of the
AviPro® 226 BTO2-REO (group 1). The remaining groups did not receive any killed vaccine and served
as primed controls. Eggs were collected and hatched from all groups of trap-nested birds for several
weeks beginning at 25 weeks of age. At 1 day of age, 40 chicks from group 1 and 30 chicks from one
of the control groups were challenged intraocularly with the Delaware variant E strain of IBD. An
additional group of 40 chicks from group 1 as well as 30 chicks from one of the control groups were
challenged at 1 day of age with the Standard Challenge strain of IBD. At 7 days post challenge, all
chicks as well as 20 unchallenged control chicks were necropsied and their bursa/body weight ratios
were determined for significant differences in the different groups. Protection was determined as
the percent of challenged birds whose bursal/body weight ratio was within one standard deviation of
the unchallenged controls’ mean bursal/body weight. Based on bursal body weight ratios, vaccination
with AviPro® 226 BTO2-REO lead to a significant (P