Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

50 Chapter 3
(Note: Similar results were obtained with this type of experiment for the
epoxide hydrolase enzyme in Problem 3).
Further reading
Intramolecular catalysis
N.S. Isaacs (1987) Physical Organic chemistry. Longman ScientiWc, Harlow.
A.J. Kirby (1980) EVective molarities for intramolecular reactions. Adv. Phys. Org.
Chem., 17, 183–278.
F.M. Menger (1985) On the source of intramolecular and enzymatic reactivity. Acc.
Chem. Res., 18, 128–34.
Enzyme catalysis
T.C. Bruice (2002) A view at the millennium: the eYciency of enzyme catalysis. Acc.
Chem. Res., 35, 139–48.
T.C. Bruice & S.J. Benkovic (2000) Chemical basis for enzyme catalysis. Biochemistry,
39, 6267–74.
A. Fersht (1985) Enzyme Structure and Mechanism, 2nd Ed. Freeman, New York.
W.P. Jencks (1969) Catalysis in Chemistry and Enzymology. McGraw-Hill, New York.
W.P. Jencks (1975) Binding energy, speciWcity and enzyme catalysis – the Circe eVect.
Adv. Enzymol., 43, 219–410.
R. Wolfenden & M.J. Snider (2001) The depth of chemical time and the power of
enzymes as catalysts. Acc. Chem. Res., 34, 938–45.
Haloalkane dehalogenase
S.M. Franken, H.J. Rozeboom, K.H. Kalk & B.W. Dijkstra (1991) Crystal structure of
haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes. EMBO J., 10,
1297–302.
F. Pries, J. Kingma, M. Pentenga, G. van Pouderoyen, C.M. Jeronimus-Stratingh, A.P.
Bruins & D.B. Janssen (1994) Site-directed mutagenesis and oxygen isotope incorporation
studies of the nucleophilic aspartate of haloalkane dehalogenase. Biochemistry,
33, 1242–7.
Dihydrofolate reductase
G.P. Miller & S.J. Benkovic (1998) Stretching exercises – Xexibility in dihydrofolate
reductase catalysis. Chemistry & Biology, 5, R105–13.