Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

Index 291
riboflavin 123, 129, 141
ribonuclease A 104–7
ribonucleic acid see RNA
ribonucleotide reductase 244–5
ribosomes 11, 258–9
ribozymes 255–9
ribulose biphosphate carboxylase/oxygenase
(Rubisco) 171–3
RNA
catalytic 255–9
cleavage 104–6
types 11, 255
Rubisco 171–3
S-adenosyl homocysteine 113
S-adenosyl homocysteine hydrolase 207
S-adenosyl methionine (SAM) 112–13,
246
S-adenosyl methionine (SAM)-dependent radical
reactions 246–9
salutaridine sythase 185
sarin 116
scurvy 148
secondary deuterium isotope effect 73–4
secondary metabolites 156
secondary structures, proteins 13–16
selectivity
defined 30
enzyme-substrate interactions 19–22
prochiral 62–7
self-splicing reaction 255–7
sequence alignment 12–13
serine hydroxymethyltransferase 114–15, 215,
220–21
serine proteases 84–9
evolution 90–91
inhibition 86–7
serotonin 214–15
shikimate pathway 193
side chains 8–10
nucleophilic catalysis 43
sinapyl alcohol 186
site-directed mutagenesis 2, 77
specific activity 53
specificity
defined 30
glycosidase enzymes 110
phosphodiesterases 104–5
steady state approximation 55
stereochemical course of reactions 60–68
at glycosyl centre 111–12
chiral products 61–2
of phosphate release 67
prochiral selectivity 62–7
pyruvate carboxylase reaction 172
stereochemical nomenclature 272–3
stereoselectivity
defined 61
hydrolysis 30
stereospecificity, defined 51
stopped flow 59–60, 68
strain energy and catalysis 45–6, 111
structure and function of enzymes 19–26
strychnine 222, 223, 224
subtilisin 88
sucrose phosphorylase 112
sulochrin oxidase 185
sulphur insertion reactions 249–50
superoxide dismutase 19
synthetic enzyme models 265–70
tautomerases, keto-enol 230–31
taxol 5
terpene cyclases 179–83
terpenes 179–80
tertiary structures, protein 16–19
tetrahydrofolate 113–14, 220
Tetrahymena thermophila ribozyme 255–7
thalidomide 6
thermodynamic model of catalysis 31
thermolysin 42, 92, 93, 94
thiamine 3, 250
thiamine pyrophoshate (TPP) 176, 178, 179
thiamine pyrophosphate-dependent
enzymes 176–9
thio-uridine 250
threonine b-epimerase 224
threonine dehydratase 218–19
thymine hydroxylase 153
TPQ 251
trans-2-phenylcylcopropylamine 132
transamination of amino acids 214, 215–18
transcarboxylase 188
transfer reactions
acyl group 99–102
glycosyl group 109
methyl group 112–13
methylene and methyne groups 113–15
phosphoryl group 102–6
transketolase enzymes 179