Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

290 Index
phenylalanine ammonia lyase 200–202
phenylalanine hydroxylase 142, 143
phenylpyruvate tautomerase 230
phosphate, elimination of 202–4
phosphate esters 102–3
phosphodiesterases 104–5
phosphoenol pyruvate 204
phosphoglucose isomerase 231
phosphonoacetaldehyde hydrolase 79
phosphonomethyl-glycine 205
phosphoramidon 93, 95
phosphorenolpyruvate 102
phosphoryl transfer reactions 102–6
and ATP 106–7
stereochemistry 67
photosynthesis 171
pK a values
and catalysis 37–40, 43
phosphate anions 202–3
PLP-dependent reactions 211–15, 220
polyketides, biosynthesis of 166–70
polymers, catalytic 269
polypeptides
hydrolysis 81–3
structure 10–13
see also protein
polysaccharides 109, 111–12
hydrolysis 81, 109–11
positional isotope exchange 70
PQQ 251–2
Prelog rule 61, 272–3
prephenic acid 233–4
primary metabolites 156
prochiral selectivity 62–7
prolyl hydroxylase 147–8
propanediol dehydrase 240–42
proteases 82–98
commercially available 83
protein dynamics 47–8
protein radicals 244–6
proteins
biosynthesis 11, 100
membrane 23–5
secondary structures 13–16
tertiary structures 16
prothrombrin 173
proximity effects 32–6
pterins 141–2
purification and extraction of enzymes 51–4
pyridine aldoximine methiodide 116
pyridoxal 5 0 -phosphate-dependent
reactions 211–15, 220
pyridoxamine 5 0 -phosphate (PMP) 215
pyridoxine 211–12
pyrophosphates 179–83
elimination reactions 202–4
pyrroloquinone (PQQ) 251–2
pyruvate carboxylase reaction 172
pyruvate decarboxylase 177
pyruvate formate lyase 246–7, 249
pyruvate oxidase 189
quinine 4
quinoproteins 250–52
racemases
cofactor-independent 227–30
PLP-dependent 212, 213
racemic mixtures, resolving 5
radical coupling 184–7
radicals in enzyme catalysis 240–52
biotin synthase and sulphur insertion 249–50
oxidised amino acid cofactors 250–52
protein radicals 244–6
quinoproteins 250–52
S-adenosyl methionine-dependent
reactions 246–9
vitamin B 12 -dependent rearrangements 240–44
radiochemical assay 51–2
rates of reaction 29–32
diffusion limit 47
rate determining step 71–4
reaction mechanism, study of 51–75
redox chemistry 23, 121–53
a-ketoglutarate dioxygenases 147–8
classes of enzymes 130
deazaflavins and pterins 141–2
electron transfer processes 121
flavin-dependent dehydrogenases and
oxidases 129–34
flavin-dependent mono-oxygenases 134–41
iron-sulphur clusters 142–3
metal dependant mono-oxygenases 143–7
NAD-dependent dehydrogenases 123–9
non-haem iron-dependent dioxygenases 148–51
redox potentials 121–3, 141
reductases 136
reduction see redox
resveratrol synthase 188
reversible inhibition 57–9