Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

Index 289
membrane-associated enzymes 23–4
menthol 179–80
metal chelating agents 92–3
metal-dependent mono-oxygenases 143–7
metallo-enzymes 22–3
metalloproteases 92–5
methionine g-lyase 219–20
methyl group transfer 112–15
methylamine dehydrogenase 251
methylaspartase 202
methylene group transfer 113–14
methylene-imidazalone cofactor 200, 202
methyleneglutarate mutase 252
methylmalonyl coenzyme A (CoA)
mutase 240–43
methyne group transfer 113–14
methyne-tetrahydrofolate 114–15
mevalonate pyrophosphate decarboxylase 203
mevalonic acid 165
Michaelis constant 56–8
Michaelis–Menten model 55–9
molybdopterin 250
monoamine oxidase 132–4
mono-oxygenases
flavin-dependent 134–7
metal-dependent 143
and pterins 142
monoterpenes 180–81
morphine 4, 222–4
mRNA 11
mutagenesis, site-directed 2, 77
N-acetylneuraminic acid 187
NAD see nicotimamide adenine dinucleotide
NAD-dependent dehydrogenases 123–9
nickel ion 142
nicotinamide 141
nicotinamide adenine dinucleotide (NAD) 121,
123, 129
oxidised form (NAD þ ) 121, 123–5, 126
phosphorylated (NADP) 123–5, 135–7, 139, 144
reduced form (NADH) 51, 123–5, 127, 139, 149
nicotinamide adenine dinucleotide-dependent
dehydrogenases 123–9
nicotine 222, 223, 224
NIH shift 142
NMR spectroscopy
intermediate detection 68
and protein structure 18, 77
and stereochemical elucidation 63–4, 67
non-haem iron-dependent dioxygenases 147,
148–51
non-polar interactions 21
N-pyruvoyl-dependent amino acid
decarboxylases 222
nucleases 104–5
nucleophilic catalysis 41–5
oligosaccharides 111–12
one-carbon transfers 112
organophosphorus inhibitors 86
orsellinic acid 166–7
oxaloacetate 215
oxidases 129–34, 185, 251
defined 121
oxidation see redox
oxidised amino acid cofactors 250–52
oxygenases 171
a-ketoglutarate-dependent dioxygenases 147–8
defined 121
flavin-dependent mono-oxygenases 134–7
metal-dependent mono-oxygenases 143–7
non-haem iron-dependent dioxygenases 148–51
p-chloromercuribenzoate 89
p-hydroxybenzoate hydroxylase 135, 136
p-hydroxycinnamyl alcohol 186
P 450 mono-oxygenases 143–7, 185
P450cam 145, 146
papain 89, 90, 91
parathion 116
penicillin acylase 5
penicillin G 4, 5
pentalene synthase 181–3, 184
PEP carboxylase 188
pepstatin 95
peptidases 81, 82–98
commercially available 83
major classes 84
peptide mapping 77
peptidoglycan 101
peptidyl-proline amide bonds 237
pericyclic reactions 236
peroxidases 145
1,10-phenanthroline 92
phenolic hydroxylases 134
phenolic radical couplings 184–7
phenyl esters, intramolecular hydrolysis of 33–5
phenyl maleate 35
phenyl succinate 34–5