Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

288 Index
glycosylation 26–7
glysophate 205–6
group transfer reactions see transfer reactions
haem cofactor 143–4
haem-dependent enzymes 145
haemoglobin 17
hairpin ribozyme 257–8
haloalkane dehalogenase 44–5, 49
haptens 261–3
helical wheel 26–7
histidine 39
histidine ammonia lyase 200
histidine decarboxylase 222
history and discovery of enzymes 1–3
HIV virus 25
HIV-1 protease 82, 95, 96–8
hydratases 194–9
hydride transfer 132, 137
hydrogen bonding
enzyme-substrate interactions 20–21
and protein folding 14, 15
hydrogen tunnelling 73
hydrolases, classes of 81–2
hydrolysis
and catalytic antibodies 261–3
cyclodextrin-catalysed 267–8
and group transfer reactions 81–115
intramolecular 34–5
phosphate esters 102–3
rates 29, 33–5
stereoselectivity 30
hydrophilic side chains 8–10, 17, 24
hydrophobic interactions 21–2
hydrophobic side chains 8–10, 17, 24
hydroxylamine 69
hydroxylation reactions 135–6, 143–8
2-hydroxypentadienoic acid hydratase 54
hyoscymine 252
hypoglycin A 131, 133
imines in alkaloid biosynthesis 222–4
influenza virus 25
inhibition, enzyme 57–9
acetylcholinesterase 116
acyl CoA dehydrogenase 131, 133
alanine racemase 213
aspartyl proteases 95
and drug design 6–7
EPSP by glyphosate 205–6
HIV-protease 97–8
irreversible 76–7
mevalonate pyrophosphate decarboxylase 203
monoamine oxidase 132–4
thermolysin 93, 95
insertion reactions 249–50
intermediates in enzymatic reactions 68–71
themodynamic model 31–2
iron-sulphur clusters 142–3, 197–8, 207
isomerases 227–36
allylic 231–3
chorismate mutase 233–6
epimerases and racemases, cofactorindependent
227–30
keto-enol tautomerases 230–31
racemases, PLP-dependent 213–14
isopentyl pyrophosphate 203
isopentyl pyrophosphate isomerase 232–3
isotopes
exchange 70–71
and intermediate analysis 72–5, 97
for stereochemical study 63–4
kaurene synthetase 189
keto-enol tautomerases 230–31
ketosteroid isomerase 40–41, 231
and kinetic isotope effect 74–5
kinase enzymes 108
kinetic competence 71
kinetic isotope effects 72–4
kinetics
of enzymatic reactions 51–60
and stereochemistry 60
kynureninase 225
lactate dehydrogenase 121, 123
Lewis acids 22, 41, 92, 95
ligase enzymes 108
lignin biosynthesis 185–7, 205
Lineweaver–Burk plot 58
lipases 30, 98–9
lipoamide 178–9
lupinine 222–3
lysine 236
lysine 2,3-aminomutase 247–9
lysozyme 110, 111
magnesium ion 22–3, 41, 183
malate synthase 65–6, 165–6
mandelate racemase 229–30