Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

Index 287
cytidine 114, 115
cytochrome 17
deazaflavins 141–2
decarboxylation 42–3, 168, 222
a-keto acids 176–9
amino acids 213–14
dehydratases 194–9, 207
dehydrogenases 123–34, 251
flavin-dependent 129–34
NAD-dependent 123–9
3-dehydroquinate dehydratase 194–6
demethylation reactions 145, 146
5 0 -deoxyadenosyl radical 242, 248
deuterium oxide isotope effect 74–5
2,6-diaminopimelic acid 236
diffusion limit 47
dihydrofolate reductase 48
dihydroxy acid dehydratase 207
3,4-dihydroxyphenylalanine
decarboxylase 214–15
dioxetane 149–50
dioxygenases
a-ketoglutarate-dependent 147
dihydroxylating 149
non-haem iron-dependent 148–51
discovery of enzymes and coenzymes 1–3
DNA 10, 12, 104
l-dopa decarboxylase 214–15
drugs, synthesis of 5–6
EDTA 94
effective concentration 33
elastase 88
electron transfer
in biological systems 121
dihydroxylating dioxygenases 149
flavin and NAD compared 129–30
iron-sulphur clusters 142–3
electrophoresis 53
electrospray mass spectrometry 77
electrostatic interactions 20
elimination reactions see addition and
elimination
enamines
in aldolases 158
in alkaloid biosythesis 222–4
endo-cleavage 82
endopeptidases, specificity of 84
enolpyruvyl transferase 206
5-enolpyruvyl-shikimate-3-phosphate (EPSP)
6, 203
5-enolpyruvyl-shikimate-3-phosphate (EPSP)
synthase 68–9, 204–6
enzyme models, synthetic 265–70
epimerases, cofactor-independent 227–30
epoxide hydrolase 49
EPSP 6, 203
EPSP synthase 68–9, 204–6
erythromycin 168–70
esterases 30, 98–9
ethylene diamine tetra-acetic acid (EDTA) 92
ethylenediamine 38–9
exo-cleavage 74
extraction and purification of enzymes 51–4
factor F 420 141–2
FAD 129–30
farnesyl pyrophosphate 181–2
fatty acids, biosynthesis of 166–70
ferrodoxins 122, 149
flavin adenine dinucleotide (FAD) 129–30
flavin-dependent dehydrogenases 129–34
flavin-dependent mono-oxygenases 134–7
flavin-dependent oxidases 129–34
flavodoxin 17
folding, protein 13–14
free energy profiles 31–2, 36, 68
fructose-1,6-biphosphate aldolase 61, 158–62,
159, 162
galactose oxidase 250–51
g-aminobutyrate transaminase 224
genes 10–11
geraniol 179–80
geranyl pyrophosphate 180, 189
glutamate mutase 240, 241, 242, 244
glutamate racemase 227–8
l-glutamic acid 215
glutamine synthetase 69, 70
glutathione 137
glutathione reductase 137–41
glycine 8
glycine radical 246
glycogen 117
glycoproteins 24–6, 109
glycosidase enzymes 109–10, 117
glycoside hydrolysis 39–40, 109
rate acceleration 29
glycosyl transfer reactions 109–12